5-(2-噻吩基)异噁唑-3-羧酸乙酯合成路线 （共 9 条）
反应条件
1: 2-thienylcarbonyloxymethyl-Wang resin; Tebbe reagent in tetrahydrofuran T=25°C; Tebbe olefination; 16 h; 2: ethyl chlorooximidoacetate With triethylamine in tetrahydrofuran 3: With trifluoroacetic acid in dichloromethane T=25°C; Further stages.;
参考文献
Barrett, Anthony G. M.; Procopiou, Panayiotis A.; Voigtmann, Ulrike
Organic Letters, 2001 , vol. 3, # 20 p. 3165 - 3168
反应条件
hydrogenchloride in ethanol
参考文献
Journal of Organic Chemistry, , vol. 26, p. 1514 - 1518
反应条件
1: potassium tert-butylate / toluene / 0 - 20 °C 2: hydroxylamine hydrochloride / ethanol / 3 h / Reflux View Scheme
参考文献
Chemistry - A European Journal, , vol. 18, # 1 p. 213 - 222
反应条件
hydroxylamine hydrochloride in ethanol 3 h; Reflux;
参考文献
Salonen, Laura M.; Holland, Mareike C.; Kaib, Philip S. J.; Haap, Wolfgang; Benz, Joerg; Mary, Jean-Luc; Kuster, Olivier; Schweizer, W. Bernd; Banner, David W.; Diederich, Francois
Chemistry - A European Journal, 2012 , vol. 18, # 1 p. 213 - 222
反应条件
1: toluene-4-sulfonic acid / ethylene glycol; toluene / Reflux 2: potassium tert-butylate / toluene / 0 - 20 °C 3: hydroxylamine hydrochloride / ethanol / 3 h / Reflux View Scheme
参考文献
Chemistry - A European Journal, , vol. 18, # 1 p. 213 - 222
反应条件
1: sodium tetrahydroborate / ethanol / 0 - 20 °C 2: pyridinium chlorochromate / dichloromethane / 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 18, # 1 p. 213 - 222
反应条件
sodium tetrahydroborate in ethanol T=0 - 20°C;
参考文献
Salonen, Laura M.; Holland, Mareike C.; Kaib, Philip S. J.; Haap, Wolfgang; Benz, Joerg; Mary, Jean-Luc; Kuster, Olivier; Schweizer, W. Bernd; Banner, David W.; Diederich, Francois
Chemistry - A European Journal, 2012 , vol. 18, # 1 p. 213 - 222
反应条件
in ethanol
T=80°C; 24 h;
参考文献
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Patent: US2009/36451 A1, 2009 ;
Location in patent: Page/Page column 32 ;
反应条件
hydrazine hydrate in water; isopropyl alcohol
参考文献
Gardner,T.S. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 1514 - 1518
