2-溴-1-(1H-吡咯并[2,3-B]吡啶-3-基)-1-乙酮合成路线 （共 4 条）
反应条件
lithium aluminium tetrahydride; aluminium trichloride in ethylene glycol dimethyl ether 0.666667 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Galvez, C.; Viladoms, P.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 421 - 423
反应条件
AlCl3, aluminium chloride in dichloromethane
0.666667 h; Reflux;
参考文献
Diana, Patrizia; Carbone, Anna; Barraja, Paola; Montalbano, Alessandra; Parrino, Barbara; Lopergolo, Alessia; Pennati, Marzia; Zaffaroni, Nadia; Cirrincione, Girolamo
ChemMedChem, 2011 , vol. 6, # 7 p. 1300 - 1309
参考文献
JACKSON, Paul Francis; Manthey, Carl; Rhodes, Kenneth; Scannevin, Robert; Leonard, Kristi Anne; Barbay, Joseph Kent; Todd, Matthew; Springer, Barry A.
Patent: US2012/302573 A1, 2012 ;
反应条件
1: 1.) n-butyllithium / 1.) ether, 1,2-dimethoxyethane, -5 deg C, 1 h; 2.) 0 deg C, 5 h
2: 75 percent / AlCl3 / CS2 / 0.67 h / 50 °C
View Scheme
参考文献
Galvez, C.; Viladoms, P.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 421 - 423
