5-(氨基甲基)-2-氯苯甲酸甲酯盐酸盐合成路线 （共 5 条）
反应条件
dihydrogen peroxide in water; ethyl acetate
T=22 - 26°C; 2 h;
参考文献
Glenmark Pharmaceuticals S.A.; GHARAT, Laxmikant Atmaram; Banerjee, Abhisek; Khairatkar-Joshi, Neelima; Kattige, Vidya Ganapati
Patent: US2013/210844 A1, 2013 ;
Location in patent: Paragraph 0298; 0299 ;
反应条件
1: dihydrogen peroxide / water; 1,4-dioxane / 12 h / |Reflux
2: sodium hydroxide / water; tetrahydrofuran / 16 h / 0 - 26 °C
3: potassium carbonate / N,N-dimethyl-formamide / 18 h / 22 - 26 °C
4: dihydrogen peroxide / water; ethyl acetate / 2 h / 22 - 26 °C
View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; BANERJEE, Abhisek; PAWAR, Mahesh Yashwant; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/38308 A1, 2013 ;
反应条件
1: sulfuric acid / 16 h / 22 - 26 °C
2: dihydrogen peroxide / water; 1,4-dioxane / 12 h / |Reflux
3: sodium hydroxide / water; tetrahydrofuran / 16 h / 0 - 26 °C
4: potassium carbonate / N,N-dimethyl-formamide / 18 h / 22 - 26 °C
5: dihydrogen peroxide / water; ethyl acetate / 2 h / 22 - 26 °C
View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; BANERJEE, Abhisek; PAWAR, Mahesh Yashwant; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/38308 A1, 2013 ;
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 22 - 26 °C
2: dihydrogen peroxide / water; ethyl acetate / 2 h / 22 - 26 °C
View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; BANERJEE, Abhisek; PAWAR, Mahesh Yashwant; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/38308 A1, 2013 ;
反应条件
1: sodium hydroxide / water; tetrahydrofuran / 16 h / 0 - 26 °C
2: potassium carbonate / N,N-dimethyl-formamide / 18 h / 22 - 26 °C
3: dihydrogen peroxide / water; ethyl acetate / 2 h / 22 - 26 °C
View Scheme
参考文献
GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant Atmaram; BANERJEE, Abhisek; PAWAR, Mahesh Yashwant; KHAIRATKAR-JOSHI, Neelima; KATTIGE, Vidya Ganapati
Patent: WO2013/38308 A1, 2013 ;
