1: With thiourea in ethanol 24 h; RefluxInert atmosphere; 2: With sodium hydroxide in ethanol; water 3 h; RefluxInert atmosphere;

sodium methylate in methanol T=0°C; Deacetylation; 2 h;

1: 52 percent / pyridine / 12 h / 0 - 20 °C 2: 51 percent / 4-DMAP; Et3N / CH2Cl2 / 20 h / 20 °C 3: 87 percent / dimethylformamide / 2 h / 100 °C 4: 95 percent / HBF4; H2O / acetonitrile / 1 h / 20 °C 5: MeONa / methanol / 2 h / 0 °C View Scheme

1: 95 percent / HBF4; H2O / acetonitrile / 1 h / 20 °C 2: MeONa / methanol / 2 h / 0 °C View Scheme

1: 87 percent / dimethylformamide / 2 h / 100 °C 2: 95 percent / HBF4; H2O / acetonitrile / 1 h / 20 °C 3: MeONa / methanol / 2 h / 0 °C View Scheme

1: With sodium thiosulfate in ethanol T=20°C; Substitution; 48 h; 2: 2-(2-(2-(2-bromoethoxy)ethoxy)-ethoxy)ethanol With hydrogenchloride Hydrolysis; 2 h; Heating;