1: KOH / ethane-1,2-diol / 12 h / 80 °C 2: 35.0 mg / potassium carbonate / acetone / 5 h / Heating View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11378939', constants.ctx, '0')">Lindlar's catalyst</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />T=20&deg;C;&nbsp;3&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 100 percent / SmI₂ / tetrahydrofuran; methanol / 0.08 h / -78 &deg;C<br />2: 90 percent / hydrogen / Lindlar's catalyst / methanol / 3 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 59 percent / potassium carbonate; sodium iodide / dimethylformamide / 5 h / 20 &deg;C<br />2: 100 percent / SmI₂ / tetrahydrofuran; methanol / 0.08 h / -78 &deg;C<br />3: 90 percent / hydrogen / Lindlar's catalyst / methanol / 3 h / 20 &deg;C<br /> <br /> &nbsp;