(1-重氮-2-氧代-丙醇)-膦酸二甲酯合成路线 （共 103 条）
反应条件
potassium carbonate in methanol T=20°C; 15 h;
参考文献
Alcaide, Benito; Almendros, Pedro; Quiros, M. Teresa; Fernandez, Israel
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 818 - 826
反应条件
1: methyl β-phenylpropionate With diisobutylaluminium hydride in n-heptane; dichloromethane T=-78°C; 2: (1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester With potassium carbonate in methanol; n-heptane; dichloromethane T=20°C; Further stages.;
参考文献
Dickson, Hamilton D.; Smith, Stephon C.; Hinkle, Kevin W.
Tetrahedron Letters, 2004 , vol. 45, # 29 p. 5597 - 5599
反应条件
potassium carbonate in methanol T=20°C; Seyferth-Gilbert Homologation; 12 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 21 p. 8765 - 8780
反应条件
potassium carbonate in methanol T=20°C; 12 h; Inert atmosphere;
参考文献
Vernekar, Sanjeev Kumar V.; Qiu, Li; Zacharias, Jeana; Geraghty, Robert J.; Wang, Zhengqiang
MedChemComm, 2014 , vol. 5, # 5 p. 603 - 608
反应条件
1: Boc-Pro-N(OMe)Me With diisobutylaluminium hydride in n-heptane; dichloromethane T=-78°C; 2: (1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester With potassium carbonate in methanol; n-heptane; dichloromethane T=20°C; Further stages.;
参考文献
Ying, Weijiang; Herndon, James W.
European Journal of Organic Chemistry, 2013 , # 15 p. 3112 - 3122
反应条件
potassium carbonate in methanol T=20°C; 15 h;
参考文献
Alcaide, Benito; Almendros, Pedro; Quiros, M. Teresa; Fernandez, Israel
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 818 - 826
反应条件
potassium carbonate in methanol T=0 - 20°C; 16 h;
参考文献
Valverde, Ibai E.; Bauman, Andreas; Kluba, Christiane A.; Vomstein, Sandra; Walter, Martin A.; Mindt, Thomas L.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 34 p. 8957 - 8960
Angew. Chem., 2013 , vol. 125, # 34 p. 9126 - 9129,4
反应条件
1: tert-butyl 1-(methoxy(methyl)amino)-3-methyl-1-oxobutan-2-ylcarbamate With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 0.5 h; Inert atmosphere; 2: (1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester in methanol T=0°C; 0.5 h; Inert atmosphere; 3: With potassium carbonate in methanol T=20°C; 15 h; Inert atmosphere;
参考文献
Temperini, Andrea; Capperucci, Antonella; Degl'Innocenti, Alessandro; Terlizzi, Raffaella; Tiecco, Marcello
Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4121 - 4124
反应条件
potassium carbonate in methanol T=20°C; Molecular sieveCooling with ice;
参考文献
Boehringer Ingelheim International GmbH; ECKHARDT, Matthias; HIMMELSBACH, Frank; LANGKOPF, Elke; NOSSE, Bernd
Patent: US2013/225601 A1, 2013 ;
Location in patent: Paragraph 0260 ;
反应条件
potassium carbonate in methanol T=0 - 20°C; 3 h; Inert atmosphere;
参考文献
Usuki, Toyonobu; Yamada, Haruka; Hayashi, Takahiro; Yanuma, Hiroto; Koseki, Yohei; Suzuki, Noriyuki; Masuyama, Yoshiro; Lin, Yong Y.
Chemical Communications, 2012 , vol. 48, # 26 p. 3233 - 3235
