2-溴-5-甲基苯甲酸甲酯合成路线 （共 9 条）
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane T=100°C; 3 h; Inert atmosphereSealed tube;
参考文献
BioChromix AB; ÅSBERG, Peter; HAMMER, Kristin; OLSSON, Johan; HENRIKSSON, Martin
Patent: WO2013/36196 A1, 2013 ;
Location in patent: Page/Page column 95-96 ;
反应条件
1: 2-bromo-5-methyl-benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
T=0 - 20°C; 1 h;
2: methanol in dichloromethane
T=20°C; 3 h;
参考文献
Guo, Shenghai; Wang, Jiliang; Li, Yan; Fan, Xuesen
Tetrahedron, 2014 , vol. 70, # 14 p. 2383 - 2388
反应条件
in methanol; dichloromethane; N,N-dimethyl-formamide
参考文献
Cell Therapeutics, Inc.
Patent: US2003/153570 A1, 2003 ;
反应条件
in methanol; chloro-trimethyl-silane
参考文献
AstraZeneca UK Limited
Patent: US6200981 B1, 2001 ;
US 6200981 B1
反应条件
hydrogenchloride; copper(I) bromide; sodium nitrite in water
T=0 - 5°C; Sandmeyer reaction;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
反应条件
in methanol; diethyl ether; toluene
2 h; Inert atmosphereSchlenk technique;
参考文献
Dydio, Pawel; Reek, Joost N. H.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 14 p. 3878 - 3882
Angew. Chem., 2013 , vol. 125, # 14 p. 4132
反应条件
1: sodium hydride / tetrahydrofuran / 18 h / 20 °C / Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 100 °C / under air
View Scheme
参考文献
Zhao, Jie; Zhao, Yufen; Fu, Hua
Angewandte Chemie - International Edition, 2011 , vol. 50, # 16 p. 3769 - 3773
反应条件
N-bromosuccinmide in tetrachloromethane
Reflux;
参考文献
Chang, Dong-Jo; Yoon, Eun-Young; Lee, Geon-Bong; Kim, Soon-Ok; Kim, Wan-Joo; Kim, Young-Myeong; Jung, Jong-Wha; An, Hongchan; Suh, Young-Ger
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4416 - 4420
反应条件
1: PdCl2(dppf); K3PO4 / 1,2-dimethoxy-ethane / 16 h / Heating
2: 1 N aq. NaOH / ethanol / 5 h / Heating
View Scheme
参考文献
Ksander; DeJesus; Yuan; Fink; Moskal; Carlson; Kukkola; Bilci; Wallace; Neubert; Feldman; Mogelesky; Poirier; Jeune; Steele; Wasvery; Stephan; Cahill; Webb; Navarrete; Lee; Gibson; Alexander; Sharif; Hospattankar
Journal of Medicinal Chemistry, 2001 , vol. 44, # 26 p. 4677 - 4687
