1,2-二(溴甲基)苯合成路线 （共 196 条）
反应条件
1: 63 percent / Bu4NBr, NaOH / H2O; toluene / 5 h / 80 °C 2: 88 percent / potassium tert-butoxide / tetrahydrofuran / 6 h / from dry ice temperature to room temperature View Scheme
参考文献
Soni, Rina; Collinson, John-Michael; Clarkson, Guy C.; Wills, Martin
Organic Letters, 2011 , vol. 13, # 16 p. 4304 - 4307
反应条件
in N,N-dimethyl-formamide 3 h; Reflux;
参考文献
Okazaki, Takao; Adachi, Taisuke; Kitagawa, Toshikazu
Bulletin of the Chemical Society of Japan, 2013 , vol. 86, # 4 p. 464 - 471
反应条件
1: Na / ethanol; diethyl ether / 5 h / Heating 2: KOH / H2O / 16 h / Heating 3: 0.33 h / 200 °C View Scheme
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
反应条件
1: With potassium phtalimide; hydrazine 2: With hydrogenchloride
参考文献
Yus, Miguel; Ramon, Diego J.; Prieto, Oscar
Tetrahedron Asymmetry, 2003 , vol. 14, # 9 p. 1103 - 1114
反应条件
in toluene byproducts: [C6H4(CH2PPh3)2]Br2; (Ar); Schlenk technique; soln. of dibromide in toluene was added to stirred suspn. of Pd complex in toluene; stirred for 15 min; cooled to 0°C; petroleum ether added; filtered; dried (vac.);
参考文献
Jones, Ray V.H.; Lindsell, W. Edward; Paddon-Jones, Greg C.; Palmer, Daniel D.; Preston, Peter N.; Rosair, Georgina M.; Whitton, Alan J.
Journal of Organometallic Chemistry, 2006 , vol. 691, # 11 p. 2378 - 2385
反应条件
1: dimethylformamide / 8 h / Heating 2: 24 percent / aq. LiOH / CH2Cl2 / 48 h / Ambient temperature View Scheme
参考文献
Minsky, Abraham; Rabinovitz, Mordecai
Synthesis, 1983 , # 6 p. 497 - 498
反应条件
iron(II) sulfate T=75°C; 12 h;
参考文献
Joshi, Girdhar; Adimurthy, Subbarayappa
Synthetic Communications, 2011 , vol. 41, # 5 p. 720 - 728
反应条件
sodium in toluene 24 h; Heating;
参考文献
Domiano, Paolo; Cozzini, Pietro; Claramunt, Rosa Maria; Lavandera, Jose Luis; Sanz, Dionisia; Elguero, Jose
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1992 , # 9 p. 1609 - 1620
反应条件
potassium iodide in N,N-dimethyl-formamide T=100°C; 17 h;
参考文献
Karginov, Vladimir A.; Nestorovich, Ekaterina M.; Yohannes, Adiamseged; Robinson, Tanisha M.; Fahmi, Nour Eddine; Schmidtmann, Frank; Hecht, Sidney M.; Bezrukov, Sergey M.
Antimicrobial Agents and Chemotherapy, 2006 , vol. 50, # 11 p. 3740 - 3753
反应条件
sodium hydroxide in 1,4-dioxane
T=20°C; 0.2 h;
参考文献
Subbarayappa, Adimurthy; Patoliya, Paresh U.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009 , vol. 48, # 4 p. 545 - 552
