1,2-二(溴甲基)苯合成路线 （共 196 条）
反应条件
hydroxymethanesulfinic acid sodium salt; potassium hydrogencarbonate in water; N,N-dimethyl-formamide
T=50°C; 28 h;
参考文献
Jarvis, William F.; Hoey, Michael D.; Finocchio, Alfred L.; Dittmer, Donald C.
Journal of Organic Chemistry, 1988 , vol. 53, # 24 p. 5750 - 5756
反应条件
in tetrahydrofuran
byproducts: LiBr; under inert atm.; α,α'-dibromo o-xylene added at -60°C; 30 min at -60°C; warmed to ambient temp.; stirred (1 h); hydrolyzed; extd.; dried; concd. (reduced pressure); pptd. (pentane); NMR;
参考文献
Castel, A.; Riviere, P.; Satge, J.; Desor, D.
Journal of Organometallic Chemistry, 1992 , vol. 433, # 1-2 p. 49 - 61
反应条件
in tetrahydrofuran
byproducts: LiBr; under inert atm.; α,α'-dibromo o-xylene added at -60°C; 30 min at -60°C; warmed to ambient temp.; stirred (1 h); hydrolyzed; extd.; dried; concd. (reduced pressure); pptd. (pentane); NMR;
参考文献
Castel, A.; Riviere, P.; Satge, J.; Desor, D.
Journal of Organometallic Chemistry, 1992 , vol. 433, # 1-2 p. 49 - 61
反应条件
lithium
1 h; Irradiation;
参考文献
Hamza, Abdulhamid
Structural Chemistry, 2010 , vol. 21, # 4 p. 787 - 793
反应条件
lithium in tetrahydrofuran
T=65 - 70°C; 2 h; Inert atmosphere;
参考文献
Franck, Geraldine; Brill, Marcel; Helmchen, Guenter
Organic Syntheses, 2012 , vol. 89, p. 55 - 65
反应条件
sodium in 1,4-dioxane
52 h; Heating; Further byproducts given;
参考文献
Domiano, Paolo; Cozzini, Pietro; Claramunt, Rosa Maria; Lavandera, Jose Luis; Sanz, Dionisia; Elguero, Jose
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1992 , # 9 p. 1609 - 1620
反应条件
in diethyl ether
under Ar, into stirred soln. of C6H4(CH2Br)2 in ether Ni complex introduced at -20°C over 1 h;
参考文献
Hipler, B.; Uhlig, E.
Journal of Organometallic Chemistry, 1980 , vol. 199, # 2 p. C27 - C30
反应条件
lithium in tetrahydrofuran
T=20°C; 3 h; Inert atmosphereSonication;
参考文献
Hamza, Abdulhamid
Structural Chemistry, 2010 , vol. 21, # 4 p. 787 - 793
参考文献
Baker et al.
Journal of the Chemical Society, 1945 , p. 27,29
反应条件
1: dioxane
2: sodium; liquid ammonia / anschliessendes Behandeln mit wss. Salzsaeure
View Scheme
参考文献
Carpino
Journal of the American Chemical Society, 1957 , vol. 79, p. 4427,4429
