1,2-二(溴甲基)苯合成路线 （共 196 条）
反应条件
caesium carbonate; hydrazine hydrate in tetrahydrofuran; N-methyl-acetamide; methanol; hexane; dichloromethane; chloroform; water; ethyl acetate; mineral oil
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US5457196 A1, 1995 ;
US 5457196 A
反应条件
sodium hydride in dimethyl sulfoxide
T=50°C; 2 h;
参考文献
Ridvan, Ludek; Zavada, Jiri
Tetrahedron, 1997 , vol. 53, # 43 p. 14793 - 14806
反应条件
sodium hydride in dimethyl sulfoxide
T=50°C; 2 h;
参考文献
Ridvan, Ludek; Zavada, Jiri
Tetrahedron, 1997 , vol. 53, # 43 p. 14793 - 14806
反应条件
in benzene
Alkylation; 8 h; Heating;
参考文献
Czombos, Jozsef; Aelterman, Wim; Tkachev, Alexey; Martins, Jose C.; Tourwe, Dirk; Peter, Antal; Toeth, Geza; Fueloep, Ferenc; De Kimpe, Norbert
Journal of Organic Chemistry, 2000 , vol. 65, # 18 p. 5469 - 5475
反应条件
hydroxymethanesulfinic acid sodium salt; potassium hydrogencarbonate in water; N,N-dimethyl-formamide
T=50°C; 28 h;
参考文献
Jarvis, William F.; Hoey, Michael D.; Finocchio, Alfred L.; Dittmer, Donald C.
Journal of Organic Chemistry, 1988 , vol. 53, # 24 p. 5750 - 5756
反应条件
1: 90 percent / K2CO3 / dimethylformamide / 48 h / 60 °C
2: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C
3: 92 percent / PBr3 / CH2Cl2 / 12 h / 0 °C
View Scheme
参考文献
Rajakumar, Perumal; Murali, Venghatraghavan
Tetrahedron, 2004 , vol. 60, # 10 p. 2351 - 2360
反应条件
caesium carbonate in dimethyl sulfoxide
T=80°C; 4 h; Reagent/catalystTemperatureSolvent;
参考文献
Wang, Jungang; Xiang, Jiachen; Wang, Miao; Guan, Jie; Wu, Anxin
Tetrahedron, 2014 , vol. 70, # 7 p. 1412 - 1417
反应条件
1: 69 percent / dimethylformamide / 1.) reflux, 3 h, 2.) room temp., overnight
2: conc. HCl / 1.) reflux, 3 h, 2.) refrigerator, 24 h
3: 90.5 percent / K2CO3 / H2O; CHCl3 / 16 h / Ambient temperature
View Scheme
参考文献
Groszkowski; Wesolowska
Archiv der Pharmazie, 1981 , vol. 314, # 10 p. 880 - 884
反应条件
1: 69 percent / dimethylformamide / 1.) reflux, 3 h, 2.) room temp., overnight
2: conc. HCl / 1.) reflux, 3 h, 2.) refrigerator, 24 h
3: 89.3 percent / K2CO3 / H2O; CHCl3 / 16 h / Ambient temperature
View Scheme
参考文献
Groszkowski; Wesolowska
Archiv der Pharmazie, 1981 , vol. 314, # 10 p. 880 - 884
反应条件
1: 69 percent / dimethylformamide / 1.) reflux, 3 h, 2.) room temp., overnight
2: conc. HCl / 1.) reflux, 3 h, 2.) refrigerator, 24 h
3: 76.7 percent / K2CO3 / H2O; CHCl3 / 16 h / Ambient temperature
View Scheme
参考文献
Groszkowski; Wesolowska
Archiv der Pharmazie, 1981 , vol. 314, # 10 p. 880 - 884
