1,2-二(溴甲基)苯合成路线 （共 196 条）
反应条件
sodium hydride in dimethyl sulfoxide
T=50°C; 2 h;
参考文献
Ridvan, Ludek; Zavada, Jiri
Tetrahedron, 1997 , vol. 53, # 43 p. 14793 - 14806
反应条件
1: 69 percent / dimethylformamide / 1.) reflux, 3 h, 2.) room temp., overnight
2: conc. HCl / 1.) reflux, 3 h, 2.) refrigerator, 24 h
View Scheme
参考文献
Groszkowski; Wesolowska
Archiv der Pharmazie, 1981 , vol. 314, # 10 p. 880 - 884
反应条件
sodium hydride in N,N-dimethyl-formamide
2 h; Ambient temperature;
参考文献
Bonnett, Raymond; North, Stephanie A.; Newton, Roger F.; Scopes, David I. C.
Tetrahedron, 1983 , vol. 39, # 8 p. 1401 - 1406
反应条件
1: 83 percent / Zn / dioxane / 6.5 h / 25 - 30 °C / Irradiation
2: 94 percent / Br2, pyridine / dioxane / 2 h / 25 °C
3: 1.) dimethylsulfoxide, 2.) water / 1.) toluene, 90 deg C, 2 h, 2.) toluene, 25 deg C
View Scheme
参考文献
Heffner; Joullie
Synthetic Communications, 1991 , vol. 21, # 8-9 p. 1055 - 1069
反应条件
2: conc.HCl
View Scheme
参考文献
Salman, Mohammad; Ray, Suprabhat
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 6 p. 477 - 479
反应条件
in N,N-dimethyl-formamide
3 h; Heating;
参考文献
Mourad, Aboul-fetouh E.; Nour-el-din, Ahmed M.; Hassan, Alaa A.; Doepp, Dietrich
Bulletin des Societes Chimiques Belges, 1986 , vol. 95, # 12 p. 1045 - 1052
反应条件
1: 63 percent / Li / tetrahydrofuran / 20 °C / sonication
2: 95 percent / NBS / CCl4 / Heating
3: 79 percent / t-BuOK / tetrahydrofuran / 0 - 20 °C
4: 0.87 g / Br2 / CCl4
5: 87 percent / t-BuOK / tetrahydrofuran / 0 °C
View Scheme
参考文献
Chaffins, Sterling; Brettreich, Michael; Wudl, Fred
Synthesis, 2002 , # 9 p. 1191 - 1194
反应条件
2: HCl
3: SOCl2
View Scheme
参考文献
Hadjoudis, E.; Pulima, I.
Molecular Crystals and Liquid Crystals (1969-1991), 1986 , vol. 137, p. 29 - 36
反应条件
1: Na / ethanol; diethyl ether / 5 h / Heating
2: KOH / H2O / 16 h / Heating
3: 0.33 h / 200 °C
4: 94 percent / conc. H2SO4 / 1 h / Heating
5: 1) n-BuLi / 1) THF, hexane, -78 deg C, 30 min, 2) THF, 1.5 h
View Scheme
参考文献
Schaaf; Johnson; Constantine; Bindra; Hess; Elger
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 328 - 334
反应条件
hydrosulfide exchange resin in acetonitrile
T=25°C; 0.25 h;
参考文献
Bandgar, Babasaheb P.; Pawar, Sanjay B.
Journal of Chemical Research - Part S, 1998 , # 4 p. 212 - 213
