1,2-二(溴甲基)苯合成路线 （共 196 条）
反应条件
magnesium in tetrahydrofuran 8 h; Heating;
参考文献
Traven', V. F.; Eismont, M. Yu.; Redchenko, V. V.; Stepanov, B. I.
J. Gen. Chem. USSR (Engl. Transl.), 1980 , vol. 50, # 9 p. 2007 - 2016,1621 - 1628
反应条件
potassium carbonate in butanone 14 h; Heating;
参考文献
Cordi; Berque-Bestel; Persigand; Lacoste; Newman-Tancredi; Audinot; Millan
Journal of Medicinal Chemistry, 2001 , vol. 44, # 5 p. 787 - 805
反应条件
potassium hydroxide; sodium in diethyl ether; ethanol; water
参考文献
Merrell Dow Pharmaceuticals Inc.
Patent: US5047534 A1, 1991 ;
反应条件
1: 90 percent / K2CO3 / butan-2-one / 24 h / Heating 2: 92 percent / KOH / aq. ethanol / 12 h / Heating View Scheme
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
反应条件
1: methylamine; ethanol / Erwaermen des Reaktionsprodukts mit wss. Natronlauge 2: diethyl ether View Scheme
参考文献
Wittig et al.
Justus Liebigs Annalen der Chemie, 1951 , vol. 572, p. 1,21
反应条件
1: dimethylformamide / 8 h / Heating 2: 18 percent / aq. LiOH / CH2Cl2 / 48 h / Ambient temperature View Scheme
参考文献
Okazaki, Takao; Adachi, Taisuke; Kitagawa, Toshikazu
Bulletin of the Chemical Society of Japan, 2013 , vol. 86, # 4 p. 464 - 471
反应条件
1: methanol 2: zinc chloride; tetrachloromethane / Erhitzen des Reaktionsprodukts mit Kaliumcyanid in wss. Aethanol 3: concentrated aqueous hydrochloric acid / 110 °C View Scheme
参考文献
Murahashi
Scientific Papers of the Institute of Physical and Chemical Research (Japan), 1936 , vol. 30, p. 180,188
反应条件
ammonium chloride; zinc; tris(triphenylphosphine)ruthenium(II) chloride in acetonitrile T=20°C;
参考文献
Molecules, , vol. 6, # 5 p. 472 - 476
反应条件
1: Zn / dimethylformamide 2: sulfur / 190 °C View Scheme
参考文献
Alder,K.; Fremery,M.
Tetrahedron, 1961 , vol. 14, p. 190 - 200
反应条件
1: With sodium hydroxide in acetonitrile T=20°C; 0.666667 h; 2: With sodium methylate in methanol 1 h; 3: in hydrogenchloride
参考文献
Belokon, Yuri N.; Kochetkov, Konstantin A.; Borkin, Dmitry A.
Mendeleev Communications, 2003 , vol. 13, # 3 p. 132 - 134
