1,2-二(溴甲基)苯合成路线 （共 196 条）
反应条件
in tetrahydrofuran; diethyl ether byproducts: LiBr; under inert atm.; addn. of α,α'-dibromo o-xylene at 20°C; for 1 h at 20°C; filtration;
参考文献
Castel, A.; Riviere, P.; Satge, J.; Desor, D.
Journal of Organometallic Chemistry, 1992 , vol. 433, # 1-2 p. 49 - 61
反应条件
1: diphenylphosphine oxide With cupric triflate; 1,1,3,3-tetramethyldisiloxane in toluene T=100°C; 9 h; Inert atmosphere; 2: With cesium hydroxide monohydrate in N,N-dimethyl-formamide; toluene T=20°C; 1 h; Inert atmosphereMolecular sieve; 3: 1,2-bis-(bromomethyl)benzene in N,N-dimethyl-formamide; toluene T=100°C; 24 h; Inert atmosphereMolecular sieve;
参考文献
Li, Yuehui; Das, Shoubhik; Zhou, Shaolin; Junge, Kathrin; Beller, Matthias
Journal of the American Chemical Society, 2012 , vol. 134, # 23 p. 9727 - 9732
反应条件
in tetrahydrofuran 0.5 h; Heating; Yield given;
参考文献
Hayashi, Teruyuki; Kawabata, Yasuziro; Isoyama, Toyoshiro; Ogata, Ikuei
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 11 p. 3438 - 3446
反应条件
1: With sodium hydroxide in acetonitrile T=20°C; 0.666667 h; 2: in hydrogenchloride; methanol T=50°C; 0.333333 h; 3: in ammonium hydroxide
参考文献
Kammermeier; Lerch; Sommer
Synthesis, 1992 , # 11 p. 1157 - 1160
参考文献
EXXONMOBIL RESEARCH AND ENGINEERING COMPANY; DAKKA, Jihad M.; MOZELESKI, Edmund J.; BAUGH, Lisa S.; BENITEZ, Frank, M.
Patent: WO2011/41349 A1, 2011 ;
反应条件
1: 75 percent / NaOMe / 4 h / Heating 2: 6 N aq. HCl / 4 h / Heating View Scheme
参考文献
Kammermeier; Lerch; Sommer
Synthesis, 1992 , # 11 p. 1157 - 1160
反应条件
in ethanol; water 2 h; Reflux;
参考文献
EXXONMOBIL RESEARCH AND ENGINEERING COMPANY; DAKKA, Jihad M.; MOZELESKI, Edmund J.; BAUGH, Lisa S.; BENITEZ, Frank, M.
Patent: WO2011/41349 A1, 2011 ;
Location in patent: Page/Page column 19 ;
参考文献
Kobler,H. et al.
Justus Liebigs Annalen der Chemie, 1978 , p. 1946 - 1962
参考文献
Hadjoudis, E.; Pulima, I.
Molecular Crystals and Liquid Crystals (1969-1991), 1986 , vol. 137, p. 29 - 36
反应条件
1: 3.40 g / sodium bis(trimethylsilyl)amide / tetrahydrofuran / -78 - 20 °C 2: TFA / tetrahydrofuran; H2O / 1 h 3: 90 percent / NaHCO3; NaCl / H2O; CH2Cl2 / 2 h / Heating 4: 93 percent / NaOH / H2O; methanol / 24 h / 20 °C View Scheme
参考文献
Williams, Lawrence J.; Jagadish; Lyon, Scott R.; Kloster, Robin A.; Carducci, Michael D.; Mash, Eugene A.
Tetrahedron, 1999 , vol. 55, # 50 p. 14281 - 14300
