反应条件
1: 1.) n-BuLi / 1.) THF, hexane, a) 0 deg C, 2.5 h, b) reflux, 0.5 h, 2.) THF, hexane, a) RT, 0.5 h, b) reflux, 17 h
2: 97 percent / BBr3 / CH2Cl2 / 24 h / Ambient temperature
3: 97 percent / Ag2O, Na2SO4 / diethyl ether / 0.07 h
4: 32 percent / CH2Cl2 / 0.07 h
5: aq. sodium dithionite
View Scheme
参考文献
Liberato; Byers; Dennick; Castagnoli Jr.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 1 p. 28 - 33
