1,2,3,4-四氢异喹啉合成路线 （共 340 条）
反应条件
sodium hydroxide in acetone 7 h; Ambient temperature;
参考文献
Mokrosz; Duszynska; Deren-Wesolek; Klodzinska; Kowalski; Charakchieva-Minol; Tatarczynska; Kowalska; Majka; Chojnacka-Wojcik; Misztal
Pharmazie, 1997 , vol. 52, # 6 p. 423 - 428
参考文献
Das,P.C. et al.
Indian Journal of Chemistry, 1970 , vol. 8, p. 590 - 592
反应条件
hydrogenchloride; sodium hydroxide; sulfuric acid; nitric acid in ethanol
参考文献
Japan Tobacco Inc.
Patent: US6410561 B1, 2002 ;
反应条件
1: sulfuric acid; potassium nitrate / water 2: hydrogenchloride / ethanol 3: Fremy’s salt; sodium carbonate / water 4: 3-chloro-benzenecarboperoxoic acid 5: p-toluenesulfonyl chloride / pyridine 7: 10 palladium on activated charcoal; hydrogen View Scheme
参考文献
Gutteridge, Clare E.; Hoffman, Marshall M.; Bhattacharjee, Apurba K.; Milhous, Wilbur K.; Gerena, Lucia
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 2 p. 786 - 789
反应条件
1.1: N-bromosuccinmide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere 1.2: 1 h / 20 °C / Inert atmosphere 2.1: sulfuric acid; potassium nitrate / 6 h / 0 - 60 °C / Inert atmosphere 3.1: manganese(IV) oxide / toluene / 2 h / Inert atmosphere; Reflux 4.1: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 760.05 Torr View Scheme
参考文献
Chen, Ying; Crockett, Richard D.; Wang, Xin; Larsen, Robert D.; Cui, Sheng; Faul, Margaret M.
Synlett, 2013 , vol. 24, # 3 art. no. ST-2012-Y0825-C, p. 301 - 304
反应条件
1: aqueous nitric acid; sulfuric acid / Erh. des Rktprod. mit Quecksilber(II)-acetat und wss. Essigsaeure auf 150grad 2: palladium/charcoal / Hydrogenation View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 6, p. 497,500
反应条件
1: With sulfuric acid T=0°C; 2 h; 2: With potassium nitrate T=25°C; 3: With hydrogenchloride in isopropyl alcohol T=0°C;
参考文献
Gruenenthal GmbH
Patent: US2010/234340 A1, 2010 ;
Location in patent: Page/Page column 21 ;
US 20100234340 A1
反应条件
hydrogenchloride; sodium hydroxide; sulfuric acid; nitric acid in ethanol
参考文献
Japan Tobacco Inc.
Patent: US6410561 B1, 2002 ;
反应条件
KNO3; sulfuric acid in hydrogenchloride
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
manganese(IV) oxide T=105°C; 0.0416667 - 0.0666667 h; Inert atmosphereMicrowave irradiation;
参考文献
Tetrahedron Letters, , vol. 54, # 15 p. 2010 - 2013
