1,2,3,4-四氢异喹啉合成路线 （共 340 条）
反应条件
sulfuric acid; nitric acid Erh. des Rktprod. mit Quecksilber(II)-acetat und wss. Essigsaeure auf 150grad;
参考文献
Ochiai; Nakagome
Chemical and Pharmaceutical Bulletin, 1958 , vol. 6, p. 497,500
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 48, # l p. 1759 - 1764
反应条件
urea hydrogen peroxide addition compound in methanol T=0 - 20°C; 7 h;
参考文献
Tetrahedron Letters, , vol. 52, # 52 p. 7079 - 7082
反应条件
tert.-butylhydroperoxide; 2-phenyl-1,2-benzisoselenazol-3-(2H)-one in tert-butyl alcohol 20 h; Heating;
参考文献
Polish Journal of Chemistry, , vol. 77, # 11 p. 1579 - 1586
参考文献
Tsang, Althea S.-K.; Todd, Matthew H.
Tetrahedron Letters, 2009 , vol. 50, # 11 p. 1199 - 1202
参考文献
US2003/191133 A1, ;
US 20030191133 A1
反应条件
in N,N-dimethyl-formamide 24 h; Ambient temperature;
参考文献
Ahmed, Zaheer; Kazmi, Syed Najam-ul-Hussain; Ahmad, Syed Salman; Khan, Abdul Qasim; Malik, Abdul
Synthetic Communications, 1988 , vol. 18, # 5 p. 501 - 506
反应条件
1.1: benzotriazole / benzene / 2 h / Heating 1.2: NaBH4 / tetrahydrofuran / 3 h / Heating 2.1: 10 percent aq. HCl / acetone / 20 °C View Scheme
参考文献
Paluchowska, Maria H.; Mokrosz, Maria J.; Bojarski, Andrzej; Wesolowska, Anna; Borycz, Jolanta; Charakchieva-Minol, Sijka; Chojnacka-Wojcik, Ewa
Journal of Medicinal Chemistry, 1999 , vol. 42, # 24 p. 4952 - 4960
反应条件
1: potassium hydride; triethylamine / 1,2-dimethoxy-ethane / 0 - 20 °C 2: 0.43 g / acetonitrile / Heating View Scheme
参考文献
Graulich; Mercier; Scuvee-Moreau; Seutin; Liegeois
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 4 p. 1201 - 1209
反应条件
9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0) in toluene T=20 - 50°C; 18 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2006/28957 A1, 2006 ;
Location in patent: Page/Page column 140 ;
WO 2006/028957 A1
