1,2,3,4-四氢异喹啉合成路线 （共 340 条）
反应条件
n-butyllithium; magnesium bromide
multistep reaction, camphor-derived auxiliary for the diastereoselective asymmetric addition of metalated tetrahydroisoquinolines to aldehydes; other substituted tetrahydroquinolines;
参考文献
Zhang, Pingsheng; Gawley, Robert E.
Tetrahedron Letters, 1992 , vol. 33, # 21 p. 2945 - 2948
反应条件
triethylamine in tetrahydrofuran
T=20°C; 10 h;
参考文献
QUEEN'S UNIVERSITY AT KINGSTON
Patent: WO2008/58402 A1, 2008 ;
Location in patent: Page/Page column 101-102 ;
反应条件
benzoic acid in toluene
T=200°C; 0.333333 h; Microwave irradiationSealed tube; Overall yield = 63 percent; regioselective reaction;
参考文献
Ma, Longle; Chen, Weijie; Seidel, Daniel
Journal of the American Chemical Society, 2012 , vol. 134, # 37 p. 15305 - 15308
反应条件
1: in chloroform
T=0 - 20°C; 1 h;
2: With hydrogenchloride in dichloromethane; chloroform; water
3: With sodium hydrogencarbonate in dichloromethane; chloroform; water
参考文献
MITSUBISHI PHARMA CORPORATION
Patent: WO2004/87124 A1, 2004 ;
Location in patent: Page/Page column 44 ;
WO 2004/087124 A1
反应条件
water; Rh6(CO)12 in 2-methoxy-ethanol
T=150°C; P=41188.4 Torr; 24 h;
参考文献
Murahashi; Imada; Hirai
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 9 p. 2968 - 2976
反应条件
styrene; [Ru(η4-COD)(η3-methylallyl)2]; potassium tert-butylate; ICy*HCl in toluene
T=125°C; 24 h; Inert atmosphereGlovebox;
参考文献
Ortega, Nuria; Richter, Christian; Glorius, Frank
Organic Letters, 2013 , vol. 15, # 7 p. 1776 - 1779
反应条件
palladium/alumina; hydrogen in octane
T=130°C; P=22502.3 Torr; 24 h; Autoclave;
参考文献
Cui, Xinjiang; Zhang, Yan; Deng, Youquan; Shi, Feng
Chemical Communications, 2014 , vol. 50, # 2 p. 189 - 191
反应条件
sodium hydroxide in ethanol; water
T=27°C; 9 h;
参考文献
Preedasuriyachai, Patcharee; Kitahara, Hiroaki; Chavasiri, Warinthorn; Sakurai, Hidehiro
Chemistry Letters, 2010 , vol. 39, # 11 p. 1174 - 1176
反应条件
tris(2,2,2-trifluoroethyl) borate in acetonitrile
T=100°C; 5 h; Sealed tube; Time;
参考文献
Lanigan, Rachel M.; Starkov, Pavel; Sheppard, Tom D.
Journal of Organic Chemistry, 2013 , vol. 78, # 9 p. 4512 - 4523
参考文献
Meyers, A. I.; Fuentes, Lelia M.; Kubota, Yoshikazu
Tetrahedron, 1984 , vol. 40, # 8 p. 1361 - 1370
