1,2,3,4-四氢异喹啉合成路线 （共 340 条）
参考文献
Suckling, Colin J.; Murphy, John A.; Khalaf, Abedawn I.; Zhou, Sheng-ze; Lizos, Dimitris E.; van Nhien, Albert Nguyen; Yasumatsu, Hiroshi; McVie, Allan; Young, Louise C.; McCraw, Corinna; Waterman, Peter G.; Morris, Brian J.; Pratt, Judith A.; Harvey, Alan L.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2649 - 2655
反应条件
in toluene
T=25°C; Ea, ln A; Rate constantThermodynamic data;
参考文献
Maat, L.; Peereboom, M.
Bulletin des Societes Chimiques Belges, 1983 , vol. 92, # 10 p. 877 - 880
反应条件
Ti(OCH(CH3)2)N(CH2C6H3C(CH3)3O)3; dihydrogen peroxide in methanol; water
T=60°C; 0.5 h; Inert atmosphere; regioselective reaction;
参考文献
Zonta, Cristiano; Cazzola, Elisa; Mba, Miriam; Licinia, Giulia
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 16 p. 2503 - 2506
反应条件
urea hydrogen peroxide addition compound in methanol
T=0 - 20°C; 7 h;
参考文献
Abrantes, Marta; Gonalves, Isabel S.; Pillinger, Martyn; Vurchio, Carolina; Cordero, Franca M.; Brandi, Alberto
Tetrahedron Letters, 2011 , vol. 52, # 52 p. 7079 - 7082
反应条件
dihydrogen peroxide in methanol; dichloromethane; water
参考文献
The President of Osaka University
Patent: US4596874 A1, 1986 ;
反应条件
oxaziridinium tetrafluoroborate derived from N-methyl-1,2,3,4-tetrahydroisoquinoline
T=-5°C;
参考文献
Hanquet, Gilles; Lusinchi, Xavier
Tetrahedron, 1994 , vol. 50, # 42 p. 12185 - 12200
反应条件
1: 1.) NaHCO3, tert-butyl hypochlorite, 2.) KO2, 18-crown-6 ether / 1.) ether, 10 deg C, 2.) ether, 4.5 h
3: 1.) NaHCO3, tert-butyl hypochlorite, 2.) KO2, 18-crown-6 ether / 1.) ether, 10 deg C, 2.) ether, 4.5 h
View Scheme
参考文献
Scully, Frank E.; Schlager, John J.
Heterocycles, 1982 , vol. 19, # 4 p. 653 - 656
反应条件
iron tribromide; 1,2,3,4,5-pentamethylcyclopentadiene; 5-oxopyrrolidine-(R)-2-carboxylic acid in 1,2,4-trimethyl benzene
T=180°C; 36 h; Inert atmosphere;
参考文献
Zhao, Yingsheng; Foo, Siong Wan; Saito, Susumu
Angewandte Chemie - International Edition, 2011 , vol. 50, # 13 p. 3006 - 3009
反应条件
in acetonitrile
T=20°C;
参考文献
Farha, Maya A.; Koteva, Kalinka; Gale, Robert T.; Sewell, Edward W.; Wright, Gerard D.; Brown, Eric D.
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 905 - 910
反应条件
diethylaminomethylpolystyrene in dichloromethane
T=80°C; 0.5 h; microwave irradiation;
参考文献
Siu, Jason; Baxendale, Ian R.; Lewthwaite, Russell A.; Ley, Steven V.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 17 p. 3140 - 3160
