1,2,3,4-四氢异喹啉合成路线 （共 340 条）
参考文献
Okimoto, Mitsuhiro; Yoshida, Takashi; Hoshi, Masayuki; Hattori, Kazuyuki; Komata, Masashi; Numata, Kaori; Tomozawa, Kenta
Australian Journal of Chemistry, 2007 , vol. 60, # 4 p. 236 - 242
参考文献
Segal; Zablotskaya; Lukevics
Chemistry of Heterocyclic Compounds, 2005 , vol. 41, # 5 p. 613 - 624
反应条件
1: 63 percent / anhydrous K2CO3, KI / butan-2-one / 5 h / Heating
2: 54.2 percent
View Scheme
参考文献
Ferles, Miloslav; Silhankova, Alexandra; Kafka, Stanislav; Taufmann, Petr; Motacek, Tomas
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # l p. 1759 - 1764
反应条件
1: 72.6 percent
2: 42 percent
View Scheme
参考文献
Ferles, Miloslav; Silhankova, Alexandra; Kafka, Stanislav; Taufmann, Petr; Motacek, Tomas
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # l p. 1759 - 1764
反应条件
1: 65.3 percent
2: 53 percent
View Scheme
参考文献
Ferles, Miloslav; Silhankova, Alexandra; Kafka, Stanislav; Taufmann, Petr; Motacek, Tomas
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # l p. 1759 - 1764
反应条件
1: 88 percent / pyridine / CH2Cl2 / 2 h / 20 °C
2: 95 percent / CH2Cl2 / 12 h / 20 °C
View Scheme
参考文献
Lemoucheux, Laurent; Rouden, Jacques; Ibazizene, Meziane; Sobrio, Franck; Lasne, Marie-Claire
Journal of Organic Chemistry, 2003 , vol. 68, # 19 p. 7289 - 7297
参考文献
Coyle, John D.; Bryant, Laurence, R. B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2857 - 2865
参考文献
Coyle, John D.; Bryant, Laurence, R. B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 12 p. 2857 - 2865
反应条件
1.1: 50 percent / KNO3; H2SO4 / 5 - 20 °C
2.1: 94 percent / Et3N / CH2Cl2 / 1 h / Heating
3.1: FeCl3*6H2O; activated carbon / methanol / 0.33 h / Heating
3.2: 85 percent / NH2NH2*H2O / methanol / 4 h / Heating
4.1: 94 percent / TFA / CH2Cl2 / 0.25 h / Heating
5.1: H2SO4; KNO3 / 0 °C
5.2: 0.5 g / aq. HCl / methanol / 0.83 h / Heating
6.1: aq. NaNO2; aq. HCl / 2 h / 0 °C
6.2: 86 percent / aq. H3PO2 / 10 h / 40 °C
7.1: aq. HCl / methanol / 10 h / Heating
View Scheme
参考文献
Zhu, Zhengxiang; Furr, John; Buolamwini, John K.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 831 - 837
反应条件
1: 54 percent / conc. HCl, NaNO2 / H2O / 2 h / 75 °C
2: 54 percent / 1.) sodium hydrosulfite, 2.) HCl / ethanol; aq. NaOH / 4 h / 62 °C
View Scheme
参考文献
Powell, Burwell F.; Overberger, C. G.; Anselme, J.-P.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 121 - 128
