1,2,3,4-四氢异喹啉合成路线 （共 340 条）
反应条件
1: in dichloromethane
T=60°C;
2: With isatoic anhydride-N-(CH2)3-C8F17 in dichloromethane
T=60°C; 2.5 h;
参考文献
Zhang, Wei; Chen, Christine Hiu-Tung; Nagashima, Tadamichi
Tetrahedron Letters, 2003 , vol. 44, # 10 p. 2065 - 2068
反应条件
acetic acid in toluene
48 h; Heating;
参考文献
Dannhardt; Mayer; Obergrusberger; Roelcke
Archiv der Pharmazie, 1986 , vol. 319, # 11 p. 977 - 981
反应条件
triethylamine in toluene
T=100°C; 2 h;
参考文献
Contreras, Jean-Marie; Rival, Yveline M.; Chayer, Said; Bourguignon, Jean-Jacques; Wermuth, Camille G.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 730 - 741
反应条件
triethylamine in dichloromethane
T=20°C;
参考文献
Mach, Robert H.; Huang, Yunsheng; Freeman, Rebekah A.; Wu, Li; Vangveravong, Suwanna; Luedtke, Robert R.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 1 p. 195 - 202
参考文献
Wu, Chengde; Anderson, C. Eric; Bui, Huong; Dupre, Brian; Gao, Daxin; Holland, George W.; Kassir, Jamal; Li, Wen; Wang, Junmei
Patent: US2005/54850 A1, 2005 ;
反应条件
sodium carbonate in N,N-dimethyl-formamide
T=0°C; 2 h;
参考文献
YUHAN CORPORATION
Patent: WO2007/1139 A1, 2007 ;
Location in patent: Page/Page column 41 ;
反应条件
potassium carbonate
T=170°C; 2 h;
参考文献
SILVERBROOK RESEARCH PTY LTD
Patent: WO2007/2982 A1, 2007 ;
Location in patent: Page/Page column 44 ;
反应条件
toluene-4-sulfonic acid in xylenes
T=280°C; 0.333333 h; Microwave irradiation;
参考文献
Deb, Indubhusan; Seidel, Daniel
Tetrahedron Letters, 2010 , vol. 51, # 22 p. 2945 - 2947
反应条件
1: With titanium(IV) isopropylate
T=75°C; 6 h;
2: With sodium tetrahydroborate in ethanol
T=20°C; 3 h;
参考文献
Kumpaty, Hephzibah J.; Bhattacharyya, Sukanta
Synthesis, 2005 , # 13 art. no. M07404SS, p. 2205 - 2209
反应条件
1: 1,2,3,4-Tetrahydro-isoquinoline With (acryloyloxymethyl)polystyrene in N,N-dimethyl-formamide
T=20°C; Solid phase reaction; Michael addition; 18 h;
2: 1-iodo-butane in N,N-dimethyl-formamide
T=60°C; Solid phase reaction; quaternization; 24 h;
3: With N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; Solid phase reaction; Hofmann elimination; 5 h;
参考文献
Brown, Angus R.; Rees, David C.; Rankovic, Zoran; Morphy, J. Richard
Journal of the American Chemical Society, 1997 , vol. 119, # 14 p. 3288 - 3295
