1,2,3,4-四氢异喹啉合成路线 （共 340 条）
反应条件
copper (II) acetate monohydrate in para-xylene T=130°C; 1 h; Green chemistry;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 37 p. 9791 - 9795
Angew. Chem., , vol. 125, # 37 p. 9973 - 9977,5
反应条件
1: NaBH4 / methanol / 1 h / Ambient temperature 2: 97 percent / Ac2O / 1 h / 70 °C 3: 93 percent / aq. NaIO4 / methanol / 20 h / Ambient temperature 4: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 0.5 h, 2.) benzene, RT, 2 h 5: 71 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 6: 96 percent / 10percent NaOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 45, # 5 p. 813 - 819
反应条件
1: 97 percent / Ac2O / 1 h / 70 °C 2: 93 percent / aq. NaIO4 / methanol / 20 h / Ambient temperature 3: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 0.5 h, 2.) benzene, RT, 2 h 4: 71 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 5: 96 percent / 10percent NaOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 45, # 5 p. 813 - 819
反应条件
1: 65 percent / potassium carbonate / H2O; toluene; benzene / 1.) 0 deg C, 30 min; 2.) 35 deg C, 24 h 3: 92 percent / methanesulphonic acid / acetic anhydride; 1,2-dichloro-ethane / 35 °C 4: sodium bis(2-methoxyethoxy)aluminium hydride / benzene / 10 h / 80 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1977 - 1982
反应条件
sulfuric acid T=60°C; bei der elektrolytischen Reduktion;
参考文献
Monatshefte fuer Chemie, , vol. 50, p. 352
反应条件
hydrogen; nickel T=205°C; P=11400 Torr; or Ru/C, 100 atm, 150 deg C; Equilibrium constant;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 63, # 11 p. 3167 - 3174
反应条件
1: 99 percent / polyphosphoric acid / 1 h / 200 - 220 °C 2: 89 percent / sodium borohydride / ethanol / 1 h / 90 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 42, # 4 p. 647 - 659
反应条件
1: 71 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 2: 96 percent / 10percent NaOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 45, # 5 p. 813 - 819
反应条件
1: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 0.5 h, 2.) benzene, RT, 2 h 2: 71 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 3: 96 percent / 10percent NaOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 45, # 5 p. 813 - 819
