1,2,3,4-四氢异喹啉合成路线 （共 340 条）
反应条件
1: 93 percent / aq. NaIO4 / methanol / 20 h / Ambient temperature 2: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 0.5 h, 2.) benzene, RT, 2 h 3: 71 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 4: 96 percent / 10percent NaOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 45, # 5 p. 813 - 819
反应条件
1: 94 percent / aq. NaIO4 / methanol / 20 h / Ambient temperature 2: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 2 h 3: 57 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 4: 10percent NaOH / ethanol / 18 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 45, # 5 p. 813 - 819
反应条件
1: 1.) TFAA, 2.) BF3*Et2O / 1.) benzene, RT, 1 h, 2.) benzene, RT, 2 h 2: 57 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 3: 10percent NaOH / ethanol / 18 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 45, # 5 p. 813 - 819
反应条件
1: 57 percent / NaBH4, NiCl2*6H2O / methanol; tetrahydrofuran / 0.5 h / Ambient temperature 2: 10percent NaOH / ethanol / 18 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 45, # 5 p. 813 - 819
反应条件
1: neat (no solvent) 2: KCN; H2O View Scheme
参考文献
Chemische Berichte, , vol. 99, p. 213 - 226
Ni: Org.Verb.2, 2.1.4.1, page 256 - 257
反应条件
1: methanesulphonic acid / acetic anhydride; 1,2-dichloro-ethane / 35 °C 2: 90 percent / methanesulphonic acid / acetic anhydride; 1,2-dichloro-ethane / 35 °C 3: aqueous HCl / 2-methyl-propan-2-ol / 10 h / 75 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1977 - 1982
反应条件
2: 92 percent / methanesulphonic acid / acetic anhydride; 1,2-dichloro-ethane / 35 °C 3: sodium bis(2-methoxyethoxy)aluminium hydride / benzene / 10 h / 80 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1977 - 1982
反应条件
1: methanesulphonic acid / acetic anhydride; 1,2-dichloro-ethane / 35 °C 2: 49 percent 3: aqueous NaOH / 2-methyl-propan-2-ol / 24 h / 75 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1977 - 1982
反应条件
trifluoroacetic acid Pictet-Spengler Cyclisation; 4.5 h; Neat (no solvent)Heating / reflux; Product distribution / selectivity;
参考文献
WO2006/134143 A1, ;
Page/Page column 29 ;
反应条件
trifluoroacetic acid Pictet-Spengler Cyclisation; 4.5 h; Neat (no solvent)Heating / reflux; Product distribution / selectivity;
参考文献
WO2006/134143 A1, ;
Page/Page column 29 ;
