2-(4-甲氧基-苯基氨基)-4-硝基苯甲酸合成路线 （共 4 条）
反应条件
copper(I) oxide; copper; potassium carbonate in 2-ethoxy-ethanol
T=130°C; 24 h;
参考文献
Mei, Xuefeng; August, Adam T.; Wolf, Christian
Journal of Organic Chemistry, 2006 , vol. 71, # 1 p. 142 - 149
反应条件
1: chloride derivative / 0 °C / |Reflux
2: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; caesium carbonate / 20 - 130 °C
3: methanol; lithium hydroxide hydrate / water; tetrahydrofuran / |Reflux
View Scheme
参考文献
Oh, Soo-Jin; Hwang, Seok Jin; Jung, Jonghoon; Yu, Kuai; Kim, Jeongyeon; Choi, Jung Yoon; Hartzell, H. Criss; Roh, Eun Joo; Justin Lee
Molecular Pharmacology, 2013 , vol. 84, # 5 p. 726 - 735
反应条件
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; caesium carbonate / 20 - 130 °C
2: methanol; lithium hydroxide hydrate / water; tetrahydrofuran / |Reflux
View Scheme
参考文献
Oh, Soo-Jin; Hwang, Seok Jin; Jung, Jonghoon; Yu, Kuai; Kim, Jeongyeon; Choi, Jung Yoon; Hartzell, H. Criss; Roh, Eun Joo; Justin Lee
Molecular Pharmacology, 2013 , vol. 84, # 5 p. 726 - 735
反应条件
1: 80 percent
2: 95 percent / 10percent aq. hydrochloric acid
3: 90 percent / stannous chloride, 5percent aq. hydrochloric acid / 3 h / Heating
4: 1.) sodium nitrite, 2.5percent aq. hydrochloric acid, 2.) sodium azide / 1.) 4 deg C, 1 h, 2.) 1 h
5: 50 percent / phosphorus oxychloride, conc. hydrochloric acid / 3 h / 110 °C
View Scheme
参考文献
Mueller, David M.; Hudson, Richard A.; Lee, Chuan-pu
Journal of the American Chemical Society, 1981 , vol. 103, # 7 p. 1860 - 1862
