2,4-二甲氧基苯甲酸合成路线 （共 127 条）
反应条件
sulfuric acid 14 h; Heating / reflux;
参考文献
Eggenweiler, Hans-Michael; Wolf, Michael; Buchstaller, Hans-Peter; Sirrenberg, Christian
Patent: US2010/22540 A1, 2010 ;
Location in patent: Page/Page column 30 ;
反应条件
1: 4-methoxy-2-methoxy benzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C; 0.5 h; 2: methanol With sodium tetrahydroborate in tetrahydrofuran T=0°C; 0.5 h;
参考文献
Synthesis, , # 9 art. no. M12811SS, p. 1375 - 1382
参考文献
Nishino, Hiroshi; Tsunoda, Katsunori; Kurosawa, Kazu
Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 2 p. 545 - 550
反应条件
N'',N'''''-1,8-naphthalenediyl-bis[N,N,N',N'-tetramethyl]-guanidine in N,N-dimethyl-formamide T=20°C; Kinetics;
参考文献
Gholamipour-Shirazi, Azarmidokht; Rolando, Christian
Organic Process Research and Development, 2012 , vol. 16, # 5 p. 811 - 818
反应条件
silver carbonate; copper(ll) bromide; palladium dichloride in tetrahydrofuran T=110°C; 24 h; SolventReagent/catalystTime;
参考文献
Tetrahedron Letters, , vol. 54, # 24 p. 3079 - 3081
反应条件
palladium diacetate; silver carbonate; copper(ll) bromide; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in dimethyl sulfoxide T=110°C; 36 h; Reagent/catalystSolvent;
参考文献
Peng, Xuefeng; Shao, Xiang-Feng; Liu, Zhong-Quan
Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3079 - 3081
反应条件
Pd(TFA)2; silver carbonate; tri-cyclo-hexyl-phosphine in ethylene glycol dimethyl ether; dimethyl sulfoxide T=120°C; 24 h; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 24 p. 5945 - 5949
反应条件
triphenylphosphine; silver carbonate; palladium dichloride in dimethyl sulfoxide T=130°C; 6 h; Inert atmosphere;
参考文献
European Journal of Organic Chemistry, , # 29 p. 5787 - 5790
反应条件
Pd(TFA)2; triphenylphosphine; silver carbonate in ethylene glycol dimethyl ether; dimethyl sulfoxide T=120°C; 24 h; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 51, # 24 p. 5945 - 5949
反应条件
copper(I) oxide; palladium diacetate; dimethyl sulfoxide; silver carbonate in toluene
T=110°C; 2 h; chemoselective reaction;
参考文献
Wang, Jiantao; Cui, Zili; Zhang, Yuexia; Li, Huajie; Wu, Long-Min; Liu, Zhongquan
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 3 p. 663 - 666
