2,4-二甲氧基苯甲酸合成路线 （共 127 条）
反应条件
1: SOCl2 / 24 h / 25 °C
5: polyphosphoric acid / 3 h
View Scheme
参考文献
Chuang, Carl; Lapin, Stephen C.; Schrock, Alan K.; Schuster, Gary B.
Journal of the American Chemical Society, 1985 , vol. 107, p. 4238 - 4243
反应条件
1: SOCl2 / 24 h / 25 °C
View Scheme
参考文献
Chuang, Carl; Lapin, Stephen C.; Schrock, Alan K.; Schuster, Gary B.
Journal of the American Chemical Society, 1985 , vol. 107, p. 4238 - 4243
反应条件
1: SOCl2 / 24 h / 25 °C
4: 1) CH3I, 2) aq. NaOH / 1) 3 h, 2) MeOH, reflux, 24 h
5: polyphosphoric acid / 3 h
View Scheme
参考文献
Chew, Warren; Hynes, Rosemary C.; Harpp, David N.
Journal of Organic Chemistry, 1993 , vol. 58, # 16 p. 4398 - 4404
反应条件
1: H2SO4
2: diethyl ether; sodium
View Scheme
参考文献
Perkin; Schiess
Journal of the Chemical Society, 1904 , vol. 85, p. 162
反应条件
1: oxalyl chloride / benzene / 2 h / Ambient temperature
2: 1.) AlCl3, 2.) pyridine, tetramethylammonium hydroxide / 1.) Et2O, RT, 8 h, 2.) H2O, reflux, 36 h
View Scheme
参考文献
Lin; Liou; Ko; Teng
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 1 p. 11 - 16
反应条件
1.1: thionyl chloride / 3 h / |Inert atmosphere; |Reflux
2.1: dichloromethane / 12 h / 0 - 20 °C / |Inert atmosphere
3.1: sec.-butyllithium; N,N,N',N,-tetramethylethylenediamine / tetrahydrofuran; cyclohexane / 2 h / -78 °C / |Inert atmosphere
3.2: -78 - 20 °C / |Inert atmosphere
4.1: hydrogenchloride; acetic acid; water / 12 h / |Reflux
View Scheme
参考文献
Mamidyala, Sreeman K.; Cooper, Matthew A.
Chemical Communications, 2013 , vol. 49, # 75 p. 8407 - 8409
反应条件
trichlorophosphate
4 h; Heating;
参考文献
Barraclough, P.; Beams, R. M.; Black, J. W.; Cambridge, D.; Collard, D.; et al.
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 6 p. 467 - 477
反应条件
methylamine in trichlorophosphate
参考文献
Burroughs Wellcome Co.
Patent: US4603139 A1, 1986 ;
反应条件
ammonium cerium(IV) nitrate in acetonitrile
T=80 - 85°C; 0.25 h;
参考文献
Chawla, H. Mohindra; Mittal, Ram S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 11 p. 1129 - 1131
反应条件
sulfuric acid
Erwaermen des Reaktionsprodukts mit wss. Natronlauge;
参考文献
Barger; Sargent
Journal of the Chemical Society, 1939 , p. 991,995
