2,4-二甲氧基苯甲酸合成路线 （共 127 条）
反应条件
1: 59 percent / bromine / CHCl3 / 5 h / Ambient temperature
2: thionyl chloride, dimethylformamide / toluene / 2 h / 65 °C
View Scheme
参考文献
Kondo; Takeda
Itsuu Kenkyusho Nempo, 1955 , # 6 p. 4,7; engl. Ref. S. 34, 37
Chem.Abstr., 1956 , p. 10112
反应条件
1: oxalyl chloride / benzene / 2 h / Ambient temperature
2: 1.) AlCl3, 2.) pyridine, tetramethylammonium hydroxide / 1.) Et2O, RT, 8 h, 2.) H2O, reflux, 36 h
3: 91 percent / phenol, HI / 8 h / 160 °C
View Scheme
参考文献
Lin; Liou; Ko; Teng
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 1 p. 11 - 16
反应条件
aluminium trichloride
参考文献
Liebermann; Lindenbaum
Chemische Berichte, 1908 , vol. 41, p. 1607,1615
参考文献
Liebermann; Lindenbaum
Chemische Berichte, 1908 , vol. 41, p. 1607,1615
反应条件
1: oxalyl chloride / benzene / 2 h / Ambient temperature
2: AlCl3 / diethyl ether / 8 h / Ambient temperature
View Scheme
参考文献
Lin; Liou; Ko; Teng
Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 1 p. 11 - 16
反应条件
1: AlCl3
2: hydriodic acid
View Scheme
参考文献
Liebermann; Lindenbaum
Chemische Berichte, 1908 , vol. 41, p. 1607,1615
反应条件
[bis(acetoxy)iodo]benzene; lithium iodide in 1,1,1,3,3,3-hexafluoroisopropanol
T=20°C; Hunsdiecker type reaction;
参考文献
Hamamoto, Hiromi; Hattori, Sho; Takemaru, Kaori; Miki, Yasuyoshi
Synlett, 2011 , # 11 p. 1563 - 1566
