1.1: Na2CO3*H2O; sodium carbonate / 35 °C
1.2: 3 h / 35 - 40 °C
2.1: sodium hydroxide / water; methanol / 3.25 h / 10 - 50 °C / |Inert atmosphere
3.1: sodium hydroxide / water; isopropyl alcohol / 2.5 h / 50 - 60 °C / |Inert atmosphere
3.2: 4 h / 84 °C / |Inert atmosphere
4.1: sodium azide; triethylamine; acetic acid / 7 h / 60 - 130 °C / |Inert atmosphere
4.2: 0.25 h / 80 °C / |Inert atmosphere
View Scheme
参考文献
Bridge, Andrew W.; Jones, Ronald H.; Kabir, Humayun; Kee, Alex A.; Lythgoe, David J.; Nakach, Mustafa; Pemberton, Clive; Wrightman, John A.
Organic Process Research and Development, 2001 , vol. 5, # 1 p. 9 - 15
Russell, Glen A.; Rajaratnam, Rajine; Wang, Lijuan; Shi, Bing Zhi; Kim, Byeong Hyu; Yao, Ching Fa
Journal of the American Chemical Society, 1993 , vol. 115, # 23 p. 10596 - 10604
1.1: Na2CO3*H2O; sodium carbonate / 35 °C
1.2: 3 h / 35 - 40 °C
2.1: sodium hydroxide / water; methanol / 3.25 h / 10 - 50 °C / |Inert atmosphere
View Scheme
参考文献
Bridge, Andrew W.; Jones, Ronald H.; Kabir, Humayun; Kee, Alex A.; Lythgoe, David J.; Nakach, Mustafa; Pemberton, Clive; Wrightman, John A.
Organic Process Research and Development, 2001 , vol. 5, # 1 p. 9 - 15
1: 2-Methyl quinoline With sec.-butyllithium in diethyl ether; cyclohexane
T=0 - 20°C; 1.5 h;
2: methyl iodide in diethyl ether; cyclohexane
T=0 - 20°C; 3 h;
参考文献
UNIVERSITY COLLEGE DUBLIN - NATIONAL UNIVERSITY OF IRELAND, DUBLIN; THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN; KENNEDY, Breandan; O'SULLIVAN, Jacintha; REYNOLDS, Alison; KILTY, Claire; BAXTER, Andrew Douglas
Patent: WO2014/12889 A1, 2014 ;
Location in patent: Page/Page column 38 ;
