2-甲基-3-硝基苯硼酸频那醇酯合成路线 （共 5 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; 13 h;
参考文献
CGI PHARMACEUTICALS, INC.; GENENTECH, INC.
Patent: WO2009/137596 A1, 2009 ;
Location in patent: Page/Page column 69-70 ;
WO 2009/137596 A1
反应条件
1: tBuCH2CH2B(H)NiPr2; 2-methyl-3-nitrobenzenediazonium tetrafluoroborate With biscyclopentadienyliron(II) in acetonitrile
T=20°C; 2.5 h;
2: With methanol in acetonitrile
T=0 - 20°C; 1 h;
3: 2,3-dimethylbutane-2,3-diol in diethyl ether; acetonitrile
T=20°C; 4 h; Reagent/catalyst;
参考文献
UNIVERSITE DE BORDEAUX 1; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; PUCHEAULT, Mathieu Jonathan Damien; MARCIASINI, Ludovic Daniel Alain; VAULTIER, Michel
Patent: WO2014/9169 A1, 2014 ;
Location in patent: Page/Page column 58-59 ;
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in dimethyl sulfoxide
T=85°C; 20 h;
参考文献
Zhao, Zhongdong; Zhichkin, Pavel E.; Stafford, Douglas G.; Kropf, Jeffrey E.; BLOMGREN, Peter A.; Currie, Kevin S.; Lee, Seung H.; Mitchell, Scott A.; Xu, Jianjun; Schmitt, Aaron C.
Patent: US2009/82330 A1, 2009 ;
Location in patent: Page/Page column 23-24 ;
反应条件
in diethyl ether
T=20°C; 4 h; Inert atmosphere;
参考文献
Marciasini, Ludovic D.; Vaultier, Michel; Pucheault, Mathieu
Tetrahedron Letters, 2014 , vol. 55, # 10 p. 1702 - 1705
反应条件
1.1: tetrafluoroboric acid / water / 0.17 h / 0 °C
1.2: 1 h / 0 °C
1.3: 2.5 h / 20 °C / |Inert atmosphere
2.1: diethyl ether / 4 h / 20 °C
View Scheme
参考文献
Marciasini, Ludovic D.; Richy, Nicolas; Vaultier, Michel; Pucheault, Mathieu
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 6 p. 1083 - 1088
