2,3-双(1H-吲哚-3-基)-N-苄基马来酰亚胺合成路线 （共 10 条）
反应条件
potassium hydroxide; ammonium acetate 1.) EtOH; Multistep reaction;
参考文献
Sasaki, Shigeki; Hashimoto, Tomohiro; Obana, Norihiro; Yasuda, Hideyo; Uehara, Yoshimasa; Maeda, Minoru
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 9 p. 1019 - 1022
反应条件
1: 66 percent / NaH / dimethylformamide 2: 1.) 5 M KOH, 2.) AcONH4 / 1.) EtOH View Scheme
参考文献
Sasaki, Shigeki; Hashimoto, Tomohiro; Obana, Norihiro; Yasuda, Hideyo; Uehara, Yoshimasa; Maeda, Minoru
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 9 p. 1019 - 1022
反应条件
in water; N,N-dimethyl-formamide
参考文献
Sagami Chemical Research Center; Asakai, Rei
Patent: US6589977 B1, 2003 ;
反应条件
1: indole With ethyl magnesium chloride in tetrahydrofuran; toluene
T=45°C; 0.75 h; Inert atmosphere;
2: 3,4-dibromo-2,5-dihydro-1-benzyl-1H-pyrrole-2,5-dione in tetrahydrofuran; toluene
Grignard reaction; 12 h; Inert atmosphereReflux;
参考文献
Lin, Zhenghuan; Chen, Hung Cheng; Sun, Shih-Sheng; Hsu, Chao-Ping; Chow, Tahsin J.
Tetrahedron, 2009 , vol. 65, # 27 p. 5216 - 5221
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in benzene
Ambient temperature;
参考文献
Bergman, Jan; Koch, Eva; Pelcman, Benjamin
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 16 p. 2609 - 2614
反应条件
1: 77 percent / K2CO3 / acetone / Ambient temperature
2: 1.) bhenylmagnesium bromide / 1.) ether, benzene, reflux, 2 h, 2.) HMPA, benzene, reflux, 44 h
View Scheme
参考文献
Joyce; Gainor; Weinreb
Journal of Organic Chemistry, 1987 , vol. 52, # 7 p. 1177 - 1185
反应条件
bis-triphenylphosphine-palladium(II) chloride; N-benzyl-N,N,N-triethylammonium chloride; cesium fluoride in water; toluene
T=60°C; 30 h;
参考文献
Doi, Issei; Tsuji, Genichiro; Kawakami, Kyoko; Nakagawa, Osamu; Taniguchi, Yosuke; Sasaki, Shigeki
Chemistry - A European Journal, 2010 , vol. 16, # 39 p. 11993 - 11999
反应条件
1: 92 percent / 1,3-dicyclohexylcarbodiimde, 4-dimethylaminopyridin / tetrahydrofuran / 2 h / Ambient temperature
2: 64 percent / tetrahydrofuran; toluene / 3 h
View Scheme
参考文献
Xie, Guojian; Lown, J. William
Tetrahedron Letters, 1994 , vol. 35, # 31 p. 5555 - 5558
反应条件
in diethyl ether; benzene
参考文献
Weinreb, Steven M.; Garigipati, Ravi S.; Gainor, James A.
Heterocycles, 1984 , vol. 21, # 1 p. 309 - 324
反应条件
potassium hydroxide in ethanol
1 h; Heating;
参考文献
Xie, Guojian; Lown, J. William
Tetrahedron Letters, 1994 , vol. 35, # 31 p. 5555 - 5558
