N-(2-氯-6-甲基苯基)-2-{[2-甲基-6-(1-哌嗪基)-4-嘧啶基]氨基}-1,3-噻唑-5-甲酰胺合成路线

N-(2-氯-6-甲基苯基)-2-{[2-甲基-6-(1-哌嗪基)-4-嘧啶基]氨基}-1,3-噻唑-5-甲酰胺合成路线（共 4 条）

110-85-0哌嗪

910297-51-7N-(2-氯-6-甲基苯基)-2-{[2-甲基-6-(1-哌嗪基)-4-嘧啶基]氨基}-1,3-噻唑-5-甲酰胺

参考文献

CURIS, INC.
Patent: WO2008/33746 A2, 2008 ;
Location in patent: Page/Page column 58 ;
WO 2008/033746 A2

110-85-0哌嗪+

302964-08-5N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑甲酰胺

910297-51-7N-(2-氯-6-甲基苯基)-2-{[2-甲基-6-(1-哌嗪基)-4-嘧啶基]氨基}-1,3-噻唑-5-甲酰胺+

910297-61-9达沙替尼二聚杂质

参考文献

Arora, Vinod Kumar; Christopher, Lisa Joy; Cui, Donghui; Li, Wenying
Patent: US2006/211705 A1, 2006 ;
Location in patent: Page/Page column 28 ;

110-85-0哌嗪+

302964-08-5N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑甲酰胺

910297-51-7N-(2-氯-6-甲基苯基)-2-{[2-甲基-6-(1-哌嗪基)-4-嘧啶基]氨基}-1,3-噻唑-5-甲酰胺

参考文献

Veach, Darren R.; Namavari, Mohammad; Pillarsetty, Nagavarakishore; Santos, Elmer B.; Beresten-Kochetkov, Tatiana; Lambek, Caryl; Punzalan, Blesida J.; Antczak, Christophe; Smith-Jones, Peter M.; Djaballah, Hakim; Clarkson, Bayard; Larson, Steven M.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 23 p. 5853 - 5857

910297-51-7N-(2-氯-6-甲基苯基)-2-{[2-甲基-6-(1-哌嗪基)-4-嘧啶基]氨基}-1,3-噻唑-5-甲酰胺+

105-36-2溴乙酸乙酯

910297-62-0达沙替尼羧酸乙酯

参考文献

CURIS, INC.
Patent: WO2008/33746 A2, 2008 ;
Location in patent: Page/Page column 58 ;
WO 2008/033746 A2