boron trifluoride diethyl etherate in acetonitrile T=45°C; 4 h;

methanol; ethanol; sodium methylate

1.1: hydrogenchloride / acetonitrile; water / 0.25 h / -10 - 20 °C 1.2: 0.5 h 1.3: 0.5 h / -10 - 20 °C 2.1: Ba(OH)2*8H2O / ethanol / 20 °C 3.1: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 100 °C / |Inert atmosphere 4.1: boron trifluoride diethyl etherate / acetonitrile / 4 h / 45 °C View Scheme