piperidine in pyridine
T=100°C; 18 h; Inert atmosphere;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; DANA-FARBER CANCER INSTITUTE, INC.; MAZITSCHEK, Ralph; BRADNER, James, Elliot
Patent: WO2011/19393 A2, 2011 ;
Location in patent: Page/Page column 98 ;
WO 2011/019393 A2
1: 3-Iodobenzoyl chloride With diethylamine; Wang resin in dichloromethane
T=20°C; 18 h;
2: ethyl acrylate With [Pd2(dba)2]; triethylamine in N,N-dimethyl-formamide
T=60°C; 18 h;
3: With trifluoroacetic acid in dichloromethane
参考文献
Morphy, J.Richard; Rankovic, Zoran; York, Mark
Tetrahedron Letters, 2002 , vol. 43, # 34 p. 5973 - 5975
