2-溴-1-(1-苯基-1H-吡唑-4-基)乙酮合成路线 （共 5 条）
反应条件
1: 1-Phenyl-1H-pyrazole-4-carbonyl chloride; diazomethyl-trimethyl-silane
2: With hydrogen bromide; acetic acid
T=0 - 20°C; 2 h;
参考文献
Subasinghe, Nalin L.; Ali, Farah; Illig, Carl R.; Rudolph, M. Jonathan; Klein, Scott; Khalil, Ehab; Soll, Richard M.; Bone, Roger F.; Spurlino, John C.; DesJarlais, Renee L.; Crysler, Carl S.; Cummings, Maxwell D.; Morris Jr., Philip E.; Kilpatrick, John M.; Babu, Y. Sudhakara
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3043 - 3047
反应条件
1.1: 100 percent / oxalyl chloride; DMF / CH2Cl2 / 2 h / 0 °C
2.2: 100 percent / HBr; AcOH / 2 h / 0 - 20 °C
View Scheme
参考文献
Subasinghe, Nalin L.; Ali, Farah; Illig, Carl R.; Rudolph, M. Jonathan; Klein, Scott; Khalil, Ehab; Soll, Richard M.; Bone, Roger F.; Spurlino, John C.; DesJarlais, Renee L.; Crysler, Carl S.; Cummings, Maxwell D.; Morris Jr., Philip E.; Kilpatrick, John M.; Babu, Y. Sudhakara
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3043 - 3047
反应条件
1.1: 80 percent / aq. NaOH / methanol / 2 h / Heating
2.1: 100 percent / oxalyl chloride; DMF / CH2Cl2 / 2 h / 0 °C
3.2: 100 percent / HBr; AcOH / 2 h / 0 - 20 °C
View Scheme
参考文献
Subasinghe, Nalin L.; Ali, Farah; Illig, Carl R.; Rudolph, M. Jonathan; Klein, Scott; Khalil, Ehab; Soll, Richard M.; Bone, Roger F.; Spurlino, John C.; DesJarlais, Renee L.; Crysler, Carl S.; Cummings, Maxwell D.; Morris Jr., Philip E.; Kilpatrick, John M.; Babu, Y. Sudhakara
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 12 p. 3043 - 3047
反应条件
1: diethyl ether / 0 °C
2: HBr (gas) / diethyl ether / 0.5 h
View Scheme
参考文献
Goddard
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 6 p. 1607 - 1612
反应条件
bromine; acetic acid
参考文献
Severini
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, 1891 , vol. <4> 7 II, p. 377
