(R)-2-(5-氨基-1,3,4-噁二唑-2-基)-1,1,1-三氟-2-丁醇合成路线 （共 2 条）
反应条件
potassium hydrogencarbonate in water
3 h;
参考文献
MERCK FROSST CANADA LTD.
Patent: WO2006/99735 A1, 2006 ;
Location in patent: Page/Page column 42 ;
反应条件
1: trifluoro-pyruvic acid ethyl ester; ethylmagnesium bromide
2: With hydrazine
Heating;
3: bromocyane With potassium hydrogencarbonate in water
参考文献
Ducharme, Yves; Blouin, Marc; Brideau, Christine; Chateauneuf, Anne; Gareau, Yves; Grimm, Erich L.; Juteau, Helene; Laliberte, Sebastien; MacKay, Bruce; Masse, Frederic; Ouellet, Marc; Salem, Myriam; Styhler, Angela; Friesen, Richard W.
ACS Medicinal Chemistry Letters, 2010 , vol. 1, # 4 p. 170 - 174
