3-氨基-5-(4-氯苯基)噻吩-2-甲酸甲酯合成路线 （共 7 条）
反应条件
sodium 1.) methanol or ethanol, room temp., 2.) reflux, 10 min; Yield given. Multistep reaction;
参考文献
Synthesis, , # 3 p. 275 - 276
反应条件
1: para-chloroacetophenone; N,N-dimethyl-formamide With trichlorophosphate T=20°C; 2: With hydroxylamine hydrochloride T=0 - 100°C; 3: 2-mercaptoacetic acid methyl ester With sodium methylate in N,N-dimethyl-formamide T=0°C; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 24 p. 7095 - 7107
反应条件
thionyl chloride T=0°C; 24 h; Reflux;
参考文献
European Journal of Medicinal Chemistry, , vol. 76, p. 343 - 351
反应条件
1.1: trichlorophosphate / 0.25 h / 25 °C 1.2: 0.5 h / 20 - 60 °C 1.3: 0.5 h 2.1: sodium; methanol / 0.5 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 65, p. 223 - 231
反应条件
1: With methanol; potassium hydroxide; water 2 h; Heating / reflux; 2: With sodium hydrogen sulphate in water
参考文献
WO2007/11284 A1, ;
Page/Page column 22-23 ;
WO 2007/011284 A1
反应条件
1: 3-amino-5-(4-chloro-phenyl)-tiophene-2-carboxylic acid methyl ester With potassium hydroxide in ethanol; water
1 h; microwave irradiation;
2: phosgene in ethanol; water
T=0 - 20°C;
参考文献
Le Foulon, Francois-Xavier; Braud, Emmanuelle; Fabis, Frederic; Lancelot, Jean-Charles; Rault, Sylvain
Tetrahedron, 2003 , vol. 59, # 50 p. 10051 - 10057
反应条件
1: potassium hydroxide / methanol; water / 3 h / |Reflux
2: tetrahydrofuran; toluene / 2 h / 20 °C
View Scheme
参考文献
Sahner, J. Henning; Groh, Matthias; Negri, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 223 - 231
