反应条件
1: para-bromoacetophenone; N,N-dimethyl-formamide With trichlorophosphate
T=20°C;
2: With hydroxylamine hydrochloride
T=0 - 100°C;
3: 2-mercaptoacetic acid methyl ester With sodium methylate in N,N-dimethyl-formamide
T=0°C; Further stages.;
参考文献
Tavares, Francis X.; Al-Barazanji, Kamal A.; Bigham, Eric C.; Bishop, Michael J.; Britt, Christy S.; Carlton, David L.; Feldman, Paul L.; Goetz, Aaron S.; Grizzle, Mary K.; Guo, Yu C.; Handlon, Anthony L.; Hertzog, Donald L.; Ignar, Diane M.; Lang, Daniel G.; Ott, Ronda J.; Peat, Andrew J.; Zhou, Hui-Qiang
Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 7095 - 7107