5-氨基-1-苄基-4-氰基吡唑合成路线 （共 13 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=70°C; 1.83333 h;
参考文献
WO2012/30924 A1, ;
Page/Page column 147 ;
WO 2012/030924 A1
反应条件
sodium hydride in ethanol 1.75 h; Heating;
参考文献
Kelley; Davis; McLean; Glen; Soroko; Cooper
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3884 - 3888
反应条件
potassium carbonate in N,N-dimethyl-formamide T=70°C; 1.5 h;
参考文献
Synlett, , # 1 art. no. U27905ST, p. 65 - 68
参考文献
Moyano, Elizabeth L.; Colomer, Juan Pablo; Yranzo, Gloria I.
European Journal of Organic Chemistry, 2008 , # 19 p. 3377 - 3381
反应条件
sodium methylate 2 h;
参考文献
Tetrahedron Letters, , vol. 52, # 14 p. 1561 - 1565
反应条件
hydrogenchloride; water; acetic acid; sodium nitrite T=0 - 20°C; 20 h;
参考文献
Tetrahedron Letters, , vol. 52, # 14 p. 1561 - 1565
反应条件
hydrogenchloride; acetic acid; sodium nitrite in water T=20°C; 20 h;
参考文献
European Journal of Organic Chemistry, , # 19 p. 3377 - 3381
反应条件
hydroxylamine in ethanol
4.5 h; Heating;
参考文献
Berry, David A.; Chien, Tun-Cheng; Townsend, Leroy B.
Heterocycles, 2004 , vol. 63, # 11 p. 2475 - 2494
反应条件
1.1: 83 percent / hydroxylamine / ethanol / 4.5 h / Heating
2.1: sodium; ethanol / 20 °C
2.2: 56 percent / ethanol / 12 h / Heating
3.1: 40 percent / sodium hydride in oil / dimethylformamide / 0.75 h / 100 °C
View Scheme
参考文献
Berry, David A.; Chien, Tun-Cheng; Townsend, Leroy B.
Heterocycles, 2004 , vol. 63, # 11 p. 2475 - 2494
反应条件
in acetonitrile
T=100°C; 14 h;
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
