1: 1-[(4R)-4-benzyl-2-thioxo-1,3-thiazolidin-3-yl]ethanone With titanium tetrachloride; N-ethyl-N,N-diisopropylamine in dichloromethane T=-78°C; 1 h; Inert atmosphere; 2: Caprylic Aldehyde in dichloromethane T=-78°C; 0.5 h; Inert atmosphere;

1.1: titanium tetrachloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere 1.2: 0.5 h / -78 °C / Inert atmosphere 2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.08 h / -78 °C / Inert atmosphere View Scheme