1: With piperidine in ethanol
2 h; Heating / reflux;
2: With sodium cyanide in ethanol; water
T=20 - 40°C; 17.3 h;
3: With hydrogenchloride in ethanol; water
T=20 - 100°C; 20 h; Heating / reflux;
参考文献
H. Lundbeck A/S
Patent: US6352988 B2, 2002 ;
Location in patent: Page column 25 ;
US 6352988 B2
