5-甲氧基-2-(甲基硫代)苯并咪唑合成路线 （共 5 条）
反应条件
1: 2-methylthio-5-methoxy-1H-benzimidazole With 1,4-diaza-bicyclo[2.2.2]octane; sec.-butyllithium in tetrahydrofuran; cyclohexane T=-60 - -50°C; 1 h; 2: 2-benzenesulfonyl-4-methoxy-3,5-dimethylpyridine T=-50°C; 0.5 h;
参考文献
Kuraray Co., Ltd.
Patent: US6350876 B2, 2002 ;
Location in patent: Example 23 ;
反应条件
1: 2-methylthio-5-methoxy-1H-benzimidazole With 1,4-diaza-bicyclo[2.2.2]octane; n-butyllithium in tetrahydrofuran T=0 - 5°C; 1 h; 2: 2-benzenesulfonyl-4-chlori-3,5-dimethylpyridine in tetrahydrofuran T=-40°C; 1 h;
参考文献
Kuraray Co., Ltd.
Patent: US6350876 B2, 2002 ;
Location in patent: Example 21 ;
反应条件
potassium hydroxide in ethanol; water
参考文献
Kuraray Co., Ltd.
Patent: US6197962 B1, 2001 ;
反应条件
potassium hydroxide in ethanol; water
T=5 - 10°C; 2.5 h;
参考文献
Kuraray Co., Ltd.
Patent: US6350876 B2, 2002 ;
Location in patent: Referential example 1 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane; water
参考文献
Kuraray Co., Ltd.
Patent: US6197962 B1, 2001 ;
