反应条件
1: 1.) aq. NaOH, 2.) SOCl2 / 1.) reflux, overnight, 2.) reflux, 3 d 2: 100 percent / CH2Cl2 / Ambient temperature 3: 85 percent / H2 / 5percent Pd/C / ethanol / 4 h / 3102.9 Torr / Ambient temperature 4: 1.) HCl (gas), 2.) 1 N aq. NaOH / 1.) Et2O, RT, 1 h, 2.) THF, RT, overnight View Scheme
参考文献
Monn, James A.; Valli, Matthew J.; Johnson, Bryan G.; Salhoff, Craig R.; Wright, Rebecca A.; Howe, Trevor; Bond, Ann; Lodge, David; Spangle, Larry A.; Paschal, Jonathan W.; Campbell, Jack B.; Griffey, Kelly; Tizzano, Joseph P.; Schoepp, Darryle D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 15 p. 2990 - 3000