2-甲基-2,7-二氮杂螺[4.4]壬烷-1,3,8-三酮合成路线 （共 6 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; Inert atmosphereReflux;
参考文献
Weinberg, Kamil; Stoit, Axel; Kruse, Chris G.; Haddow, Mairi F.; Gallagher, Timothy
Tetrahedron, 2013 , vol. 69, # 23 p. 4694 - 4707
参考文献
Warner-Lambert Company
Patent: US4604401 A1, 1986 ;
反应条件
in water
1.) RT, overnight, 2.) from RT to 220 deg C, 1 h;
参考文献
Culbertson, Townley P.; Sanchez, Joseph P.; Gambino, Laura; Sesnie, Josephine A.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2270 - 2275
反应条件
1: 80 percent / H2, triethylamine / Raney cobalt / dimethylformamide / 23 h / 124116 - 279260 Torr
2: 76.2 percent / H2O / 1.) RT, overnight, 2.) from RT to 220 deg C, 1 h
View Scheme
参考文献
Culbertson, Townley P.; Sanchez, Joseph P.; Gambino, Laura; Sesnie, Josephine A.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2270 - 2275
反应条件
sodium hydride
1.) DMF, 1 h, 2.) RT, overnight; Yield given. Multistep reaction;
参考文献
Warner-Lambert Co.
Patent: US4638067 A1, 1987 ;
Title/Abstract Full Text Show Details
Warner-Lambert Company
Patent: US4771054 A1, 1988 ;
反应条件
1: 1.) NaH / 1.) DMF, 1 h, 2.) RT, overnight
2: lithium aluminum hydride / tetrahydrofuran / 1.) RT, overnight, 2.) reflux, 1 h
View Scheme
参考文献
Culbertson, Townley P.; Sanchez, Joseph P.; Gambino, Laura; Sesnie, Josephine A.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2270 - 2275
