7-甲酰基-3,4-二氢-1,8-萘啶-1(2H)-羧酸叔丁酯合成路线 （共 3 条）
反应条件
sodium periodate; osmium(VIII) oxide; 4-methylmorpholine N-oxide in water; acetonitrile
T=20°C;
参考文献
Raboisson, Pierre; DesJarlais, Renee L.; Reed, Rolanda; Lattanze, Jennifer; Chaikin, Margery; Manthey, Carl L.; Tomczuk, Bruce E.; Marugan, Juan Jose
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 3 p. 334 - 343
反应条件
1: 89 percent / I2; imidazole; triethylamine / triphenylphosphine / CH2Cl2 / 0 - 25 °C
2: 53 percent / potassium tert-butoxide / tetrahydrofuran / -78 - 20 °C
3: 57 percent / sodium periodate; 4-methylmorpholine-N-oxide; OsO4 / acetonitrile; H2O / 20 °C
View Scheme
参考文献
Raboisson, Pierre; DesJarlais, Renee L.; Reed, Rolanda; Lattanze, Jennifer; Chaikin, Margery; Manthey, Carl L.; Tomczuk, Bruce E.; Marugan, Juan Jose
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 3 p. 334 - 343
反应条件
1: 53 percent / potassium tert-butoxide / tetrahydrofuran / -78 - 20 °C
2: 57 percent / sodium periodate; 4-methylmorpholine-N-oxide; OsO4 / acetonitrile; H2O / 20 °C
View Scheme
参考文献
Raboisson, Pierre; DesJarlais, Renee L.; Reed, Rolanda; Lattanze, Jennifer; Chaikin, Margery; Manthey, Carl L.; Tomczuk, Bruce E.; Marugan, Juan Jose
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 3 p. 334 - 343
