5-溴-N-叔丁氧羰基-L-正缬氨酸叔丁酯合成路线 （共 14 条）
反应条件
1: 96 percent / aq. citric acid / tetrahydrofuran
2: 94 percent / triethylamine / dimethylformamide
3: 70 percent / NaBH4; LiCl / tetrahydrofuran; ethanol / 0 °C
4: 81 percent / triphenylphosphane; bromine; imidazole / CH2Cl2 / 2 h / 0 °C
View Scheme
参考文献
Siebum, Arjan H. G.; Tsang, Robert K. F.; Van Der Steen, Rob; Raap, Jan; Lugtenburg, Johan
European Journal of Organic Chemistry, 2004 , # 21 p. 4391 - 4396
反应条件
1.1: SOCl2
2.1: dioxane
3.1: Boc2O; DMAP
4.1: NaOH / methanol; H2O
5.1: ClCOOEt; NMO
5.2: NaBH4 / methanol
5.3: 81 percent / CBr4; PPh3
View Scheme
参考文献
Bhat, Ramakrishna G.; Porhiel, Emmanuel; Saravanan, Vadivelu; Chandrasekaran, Srinivasan
Tetrahedron Letters, 2003 , vol. 44, # 28 p. 5251 - 5253
反应条件
1.1: dioxane
2.1: Boc2O; DMAP
3.1: NaOH / methanol; H2O
4.1: ClCOOEt; NMO
4.2: NaBH4 / methanol
4.3: 81 percent / CBr4; PPh3
View Scheme
参考文献
Bhat, Ramakrishna G.; Porhiel, Emmanuel; Saravanan, Vadivelu; Chandrasekaran, Srinivasan
Tetrahedron Letters, 2003 , vol. 44, # 28 p. 5251 - 5253
反应条件
1.1: Boc2O; DMAP
2.1: NaOH / methanol; H2O
3.1: ClCOOEt; NMO
3.2: NaBH4 / methanol
3.3: 81 percent / CBr4; PPh3
View Scheme
参考文献
Bhat, Ramakrishna G.; Porhiel, Emmanuel; Saravanan, Vadivelu; Chandrasekaran, Srinivasan
Tetrahedron Letters, 2003 , vol. 44, # 28 p. 5251 - 5253
