4-[(1R)-1-氨基乙基]苯甲酸甲酯合成路线 （共 11 条）
反应条件
1: With sulfuric acid Reflux; 2: With sodium hydrogencarbonate in ethyl acetate
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2011/212969 A1, 2011 ;
Location in patent: Page/Page column 141 ;
US 20110212969 A1
反应条件
potassium carbonate in methanol; water T=20°C; 24 h;
参考文献
Allwein, Shawn P.; McWilliams, J. Christopher; Secord, Elizabeth A.; Mowrey, Dale R.; Nelson, Todd D.; Kress, Michael H.
Tetrahedron Letters, 2006 , vol. 47, # 36 p. 6409 - 6412
反应条件
1: 90 percent / TFA; Fe / ethyl acetate / 65 °C 2: 95 percent / H2 / (MeBPE)Rh(COD)BF4 / methanol / 23 °C / 4654.33 Torr 3: 80 percent Chromat. / K2CO3 / methanol; H2O / 24 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 36 p. 6409 - 6412
反应条件
1: 95 percent / H2 / (MeBPE)Rh(COD)BF4 / methanol / 23 °C / 4654.33 Torr 2: 80 percent Chromat. / K2CO3 / methanol; H2O / 24 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 36 p. 6409 - 6412
反应条件
1: 100 percent / NH2OH 2: 90 percent / TFA; Fe / ethyl acetate / 65 °C 3: 95 percent / H2 / (MeBPE)Rh(COD)BF4 / methanol / 23 °C / 4654.33 Torr 4: 80 percent Chromat. / K2CO3 / methanol; H2O / 24 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 36 p. 6409 - 6412
反应条件
hydrogenchloride T=70°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 3 p. 1225 - 1228
反应条件
1: titanium(IV) isopropylate / dichloromethane / 6 h / 0 - 20 °C 2: dichloromethane; diethyl ether / 20 h / -45 - 20 °C 3: hydrogenchloride / 1,4-dioxane / 2 h / 60 °C 4: sulfuric acid / Reflux View Scheme
参考文献
US2011/212969 A1, ;
US 20110212969 A1
反应条件
1: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 16 h / 20 °C 2: titanium(IV) isopropylate / dichloromethane / 6 h / 0 - 20 °C 3: dichloromethane; diethyl ether / 20 h / -45 - 20 °C 4: hydrogenchloride / 1,4-dioxane / 2 h / 60 °C 5: sulfuric acid / Reflux View Scheme
参考文献
US2011/212969 A1, ;
US 20110212969 A1
反应条件
1: dichloromethane; diethyl ether / 20 h / -45 - 20 °C 2: hydrogenchloride / 1,4-dioxane / 2 h / 60 °C 3: sulfuric acid / Reflux View Scheme
参考文献
US2011/212969 A1, ;
US 20110212969 A1
