2,5-二甲氧基双环[4.2.0]辛-1,3,5,7-四烯-7-甲腈合成路线 (共 2 条)
反应条件
1.1: H2 / Pd/C / ethanol / 0.5 h / 1034.3 Torr
2.1: aq. HCl; isoamyl nitrite / diethyl ether; ethanol / 0.17 h / 0 °C
2.2: 231 mg / propylene oxide / 1,2-dichloro-ethane / 2 h / Heating
View Scheme
参考文献
McLean, Thomas H.; Parrish, Jason C.; Braden, Michael R.; Marona-Lewicka, Danuta; Gallardo-Godoy, Alejandra; Nichols, David E.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 19 p. 5794 - 5803
反应条件
1: 3,6-dimethoxyanthranilic acid With hydrogenchloride; isopentyl nitrite in diethyl ether; ethanol
T=0°C; 0.166667 h;
2: acrylonitrile With methyloxirane in 1,2-dichloro-ethane
2 h; Heating;
参考文献
McLean, Thomas H.; Parrish, Jason C.; Braden, Michael R.; Marona-Lewicka, Danuta; Gallardo-Godoy, Alejandra; Nichols, David E.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 19 p. 5794 - 5803