1.1: (S)-pyrophosphoric acid / water / 2 h / 0 - 60 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 - 35 °C 3.1: hydrogen / Ni-Raney / tetrahydrofuran / 48 h / 20 °C / 2585.81 - 3102.97 Torr 4.1: ethyl acetate / 96 h / 25 °C 5.1: boron trifluoride diethyl etherate; triethylsilane / 24 h / 105 °C 6.1: sodium hydroxide / dichloromethane; water / pH > 10 6.2: 2 h / 60 °C View Scheme

1.1: (S)-pyrophosphoric acid / water / 2 h / 0 - 60 °C 2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 20 - 35 °C 3.1: hydrogen / Ni-Raney / tetrahydrofuran / 48 h / 20 °C / 2585.81 - 3102.97 Torr 4.1: ethyl acetate / 96 h / 25 °C 5.1: lithium aluminium tetrahydride; AlCl3, aluminium chloride / tetrahydrofuran / 0 - 20 °C 5.2: 0.33 h / 2 °C View Scheme

<b>Multi-step reaction with 4 steps<br /> </b>1.1: potassium carbonate / copper / 10 h / 130 &deg;C<br />2.1: morpholine; sulfur / 12 h / 110 &deg;C<br />2.2: 8 h / Reflux<br />3.1: sulfuric acid / 2 h / 50 &deg;C<br />4.1: sodium t-butanolate / tert-butyl methyl ether / 2 h / 5 - 20 &deg;C<br /> <br /> &nbsp;

Stage #1: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3556712', constants.ctx, '0')">potassium <i>tert</i>-butylate</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730942', constants.ctx, '0')">tert-butyl methyl ether</a> <br />T=-10 - 0&deg;C;&nbsp;0.5&nbsp;h;&nbsp;<br />Stage #2: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730942', constants.ctx, '0')">tert-butyl methyl ether</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br /> <br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1.1: potassium carbonate / copper / 10 h / 130 &deg;C<br />2.1: morpholine; sulfur / 12 h / 110 &deg;C<br />2.2: 8 h / Reflux<br />3.1: sulfuric acid / 2 h / 50 &deg;C<br />4.1: sodium t-butanolate / tert-butyl methyl ether / 2 h / 5 - 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: sulfuric acid / 2 h / 50 &deg;C<br />2: sodium t-butanolate / tert-butyl methyl ether / 2 h / 5 - 20 &deg;C<br /> <br /> &nbsp;