5-叔丁基基-异噁唑-3-甲酸乙酯合成路线 （共 4 条）
反应条件
hydroxylamine hydrochloride in tetrahydrofuran; ethanol T=20°C; 14 h; Heating / refluxMolecular sieve;
参考文献
Chapal, Nicolas; McNicol, Patricia; Jette, Lucie
Patent: US2006/223884 A1, 2006 ;
Location in patent: Page/Page column 57-58 ;
反应条件
hydroxylamine hydrochloride; sodium hydrogencarbonate in ethanol 16 h; Reflux;
参考文献
Boehringer Ingelheim International GmbH; Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: EP2418207 A1, 2012 ;
Location in patent: Page/Page column 24 ;
反应条件
triethylamine in tetrahydrofuran T=0 - 20°C;
参考文献
WO2005/68432 A1, ;
Page/Page column 180-181 ;
反应条件
1: diethyl ether; sodium ethylate / -15 °C 2: hydroxylamine View Scheme
参考文献
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 150, p. 928
