2-苯基哌嗪-1-羧酸苄醇合成路线 （共 3 条）
反应条件
trifluoroacetic acid in dichloromethane
T=25°C; 1.5 h;
参考文献
EXELIXIS, INC.; RICE, Kenneth
Patent: WO2012/71509 A2, 2012 ;
Location in patent: Page/Page column 168 ;
WO 2012/071509 A2
反应条件
1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 3 h / 95 °C
2: trifluoroacetic acid / dichloromethane / 1.5 h / 25 °C
View Scheme
参考文献
EXELIXIS, INC.; RICE, Kenneth
Patent: WO2012/71509 A2, 2012 ;
WO 2012/071509 A2
反应条件
1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 3 h / 95 °C
2: trifluoroacetic acid / dichloromethane / 1.5 h / 25 °C
View Scheme
参考文献
EXELIXIS, INC.; RICE, Kenneth
Patent: WO2012/71509 A2, 2012 ;
WO 2012/071509 A2
