1: 1) KOH, 2) aq. H2O2 / 1) CH3OH, H2O, 15 deg C, 45 min; 2) ice water, 10 min 2: 88 percent / 0.5 h / 160 °C View Scheme

1: 1) KOH, 2) aq. H2O2 / 1) CH3OH, H2O, 15 deg C, 45 min; 2) ice water, 10 min 2: 98 percent / SOCl2, DMF / CH2Cl2 / 2 h / 20 °C 3: 92 percent / NaOEt / ethanol; dimethylformamide / 1 h 4: NaOH / ethanol; H2O 5: 0.5 h / 160 °C View Scheme